Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
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DOI：
10.1158/1055-9965.epi-09-0841
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Riboli E
中科院分区：
文献类型：
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作者：
Eussen SJ;Vollset SE;Igland J;Meyer K;Fredriksen A;Ueland PM;Jenab M;Slimani N;Boffetta P;Overvad K;Tjønneland A;Olsen A;Clavel-Chapelon F;Boutron-Ruault MC;Morois S;Weikert C;Pischon T;Linseisen J;Kaaks R;Trichopoulou A;Zilis D;Katsoulis M;Palli D;Berrino F;Vineis P;Tumino R;Panico S;Peeters PH;Bueno-de-Mesquita HB;van Duijnhoven FJ;Gram IT;Skeie G;Lund E;González CA;Martínez C;Dorronsoro M;Ardanaz E;Navarro C;Rodríguez L;Van Guelpen B;Palmqvist R;Manjer J;Ericson U;Bingham S;Khaw KT;Norat T;Riboli E
叶酸在结直肠癌（CRC）中的潜在双重作用目前仍存在争议。以前关于血浆叶酸和结直肠癌风险的研究规模较小且不确定。因此，我们研究了血浆叶酸，一些相关的叶酸相关的多态性和CRC风险之间的关联。在欧洲癌症与营养前瞻性研究（EPIC）队列的巢式病例对照研究中，1367例新发CRC病例与2325例对照病例在研究中心、年龄和性别上相匹配。风险比（RR）采用条件Logistic回归进行估计，并进一步调整吸烟，教育，体育活动，酒精和纤维摄入量。总体分析未显示血浆叶酸与CRC相关。叶酸水平第五组与第一组的RR（95% CI，P趋势）为0.94（（0.74; 1.20），0.44）。MTHFR 677 C →T、MTHFR 1298 A →C、MTR 2756 A →G、MTRR 66 A →G和MTHFD 1 1958 G →A多态性与结直肠癌风险无关。然而，在血浆叶酸浓度最低的个体中，MTHFR 677 TT基因型显示CRC风险增加无统计学意义（RR（95% CI，P趋势）TT vs. CC =1.39（0.87; 2.21），0.12），而在那些叶酸浓度最高的人中，CRC风险没有显着降低（RR TT与CC=0.74（0.39; 1.37），0.34）。SLC 19 A1 80 G →A与CRC风险呈正相关（RR AA vs. GG 1.30（1.06; 1.59），<0.01）。在这项大型欧洲前瞻性多中心研究中，我们没有观察到CRC风险与血浆叶酸水平或MTHFR多态性的相关性。
A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. Previous studies on plasma folate and CRC risk were small and inconclusive. We therefore investigate associations between plasma folate, a number of relevant folate-related polymorphisms and CRC risk. In this nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1367 incident CRC cases were matched to 2325 controls for study center, age and sex. Risk ratios (RR) were estimated with conditional logistic regression and further adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% CI), Ptrend) for the fifth vs. the first quintile of folate status was 0.94 ((0.74; 1.20), 0.44). The polymorphisms MTHFR 677C→T, MTHFR 1298A→C, MTR 2756A→G, MTRR 66A→G, and MTHFD1 1958G→A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically non-significant increased CRC risk (RR (95% CI, Ptrend) TT vs. CC =1.39 (0.87; 2.21), 0.12), whereas in those with the highest folate concentrations showed a non-significant decreased CRC risk (RR TT vs. CC=0.74 (0.39; 1.37), 0.34). The SLC19A1 80G→A showed a positive association with CRC risk (RR AA vs. GG1.30 (1.06; 1.59), <0.01). Within this large European prospective multicenter study we did not observe an association of CRC risk with plasma folate status, nor with the MTHFR polymorphisms.