Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
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DOI：
10.1038/ncb2015
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发表时间：
2010-02
影响因子：
21.3
通讯作者：
Rossi FM
中科院分区：
文献类型：
--
作者：
Joe AW;Yi L;Natarajan A;Le Grand F;So L;Wang J;Rudnicki MA;Rossi FM
有效的组织再生取决于多种细胞类型的协调反应。在这里，我们描述了一个新的亚群的脂肪/成脂祖细胞（FAP）驻留在肌肉组织中，但从一个独特的发展谱系。当在脂肪浸润模型中皮下或肌内递送时，纯化的FAP的移植导致异位白色脂肪的产生，但在健康肌肉中不产生，这表明环境控制它们的植入。这些细胞在完整的肌肉中是静止的，但在损伤时有效地增殖。FAP不产生肌纤维，但在共培养实验中提高了原代肌源性祖细胞的分化率。总之，FAP在损伤后扩增，为增殖的肌源性祖细胞提供促分化信号的瞬时来源。
Efficient tissue regeneration is dependent on the coordinated responses of multiple cell types. Here, we describe a new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage. Transplantation of purified FAPs results in the generation of ectopic white fat when delivered subcutaneously or intramuscularly in a model of fatty infiltration, but not in healthy muscle, suggesting that the environment controls their engraftment. These cells are quiescent in intact muscle but proliferate efficiently in response to damage. FAPs do not generate myofibres, but enhance the rate of differentiation of primary myogenic progenitors in co-cultivation experiments. In summary, FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors.