Regulation of autoimmune diabetes by interleukin 3-dependent bone marrow-derived cells in NOD mice.
Regulation of autoimmune diabetes by interleukin 3-dependent bone marrow-derived cells in NOD mice.
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NOD 小鼠中白细胞介素 3 依赖性骨髓衍生细胞对自身免疫糖尿病的调节。
DOI：
10.1006/jaut.1997.0142
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Maki,T
中科院分区：
文献类型：
--
作者：
Ito,A;Aoyanagi,N;Maki,T
Interleukin-3 (IL-3), a multilineage colony stimulating factor, has been shown to augment alloreactive bone marrow-derived suppressor cell activity in vivo and in vitro. The present study examined the effect of IL-3 on autoimmune-mediated diabetes in NOD mice. Administration of IL-3 twice weekly starting at 2–4 weeks of age delayed the onset and reduced the overall incidence of diabetes. Bone marrow cells obtained from IL-3-treated NOD mice protected NOD mice from cyclophosphamide-induced diabetes but failed to prevent adoptively transferred diabetes. In vitro culture of bone marrow cells in medium containing IL-3 produced a Thy-1+CD3ϵloCD4−CD8−CD25−immature T cell clone which prevented cyclophosphamide-induced diabetes. The cloned cells also effectively delayed the development of diabetes induced by transfer of T cells in adult thymectomized, irradiated, bone marrow-reconstituted NOD mice. These results suggest that IL-3 is capable of regulating extrathymic T cell development from the bone marrow and that these cells mediate strong immunoregulatory function.
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肥大细胞生长因子和 IL-3 支持骨髓驻留 T 细胞前体的体外生长。
影响因子：
4.4
作者：
R. Chervenak;D. Dempsey;R. Soloff;G. Smithson
通讯作者：
G. Smithson
DOI：
10.1073/pnas.89.8.3434
发表时间：
1992-04-15
影响因子：
11.1
作者：
MAKI, T;ICHIKAWA, T;PORTER, J
通讯作者：
PORTER, J
胰岛素依赖型糖尿病：最初的病变。
影响因子：
158.5
作者：
G. Cahill;H. Mcdevitt
通讯作者：
H. Mcdevitt
保护性主要组织相容性复合物 II 类分子未能删除自身免疫性糖尿病中的自身反应性 T 细胞。
DOI：
10.1073/pnas.90.22.10808
发表时间：
1993
影响因子：
11.1
作者：
Robyn M. Slattery;Jacques F. A. P. Miller;William R. Heath;Brett Charlton
通讯作者：
Brett Charlton
IL-3 增强 2 型 CD4 T 细胞的 TCR 介导的反应。
影响因子：
4.4
作者：
Y. Dan;Y. Katakura;A. Ametani;S. Kaminogawa;Y. Asano
通讯作者：
Y. Asano