Expression of rh glycoproteins in the Mammalian kidney.
Expression of rh glycoproteins in the Mammalian kidney.
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DOI：
10.5049/ebp.2009.7.1.14
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Weiner ID
中科院分区：
文献类型：
--
作者：
Han KH;Kim HY;Weiner ID
氨代谢是维持所有生物体生命的基本过程。最近的研究已经确定了酵母（Mep），植物（MEP）和哺乳动物（Rh糖蛋白）中的氨转运蛋白家族蛋白。在哺乳动物肾脏中，氨代谢和转运对于调节系统性酸碱平衡至关重要，基底外侧Rh B糖蛋白和顶端/基底外侧Rh C糖蛋白沿着远端肾单位节段表达。来自实验动物模型和基因敲除小鼠的数据表明，Rh糖蛋白似乎介导尿氨排泄的重要作用。
Ammonia metabolism is a fundamental process in the maintenance of life in all living organisms. Recent studies have identified ammonia transporter family proteins in yeast (Mep), plants (Amt), and mammals (Rh glycoproteins). In mammalian kidneys, where ammonia metabolism and transport are critically important for the regulation of systemic acid-base homeostasis, basolateral Rh B glycoprotein and apical/basolateral Rh C glycoprotein are expressed along the distal nephron segments. Data from experimental animal models and knockout mice suggest that the Rh glycoproteins appear to mediate important roles in urinary ammonia excretion.