Programming Fluid Transport in Paper-Based Microfluidic Devices Using Razor-Crafted Open Channels
Programming Fluid Transport in Paper-Based Microfluidic Devices Using Razor-Crafted Open Channels
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DOI：
10.1021/ac501273v
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发表时间：
2014-07-01
影响因子：
7.4
通讯作者：
Vlessidis, Athanasios G.
中科院分区：
文献类型：
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作者：
Giokas, Dimosthenis L.;Tsogas, George Z.;Vlessidis, Athanasios G.
在微流控、纸基分析设备(MUPAD)中操纵流体传输是在同一设备上实现多个定时分析步骤的基本前提。当前控制流体分布的方法主要依赖于控制流体在设备内移动的速度或通过激活开/关开关来流动。在这篇文章中，我们提出了一种简单的方法来编程纸基设备中的流体传输，该方法可以在没有主动泵送的情况下实现流体传输的加速和延迟。这两种操作都是通过使用配备刀刃的工艺切割工具在流道上纵向或垂直地切割明渠来编程的。通道是在MU衬垫制造之后制作的，使得终端用户能够通过雕刻纸张的多孔性材料来根据需要产生开放通道的图案，而无需完全切割或移除纸张衬底。控制水流加速或延迟的参数包括明渠的方向、长度和数量。使用这种方法，在同一设备上实现了加速和降低的流体传输速率。该方法被应用于MU PADS，用于金属离子的多次和时间可编程分析。
Manipulating fluid transport in microfluidic, paper-based analytical devices (mu PADs) is an essential prerequisite to enable multiple timed analytical steps on the same device. Current methods to control fluid distribution mainly rely on controlling how slowly the fluid moves within a device or by activating an on/off switch to flow. In this Article, we present an easy approach for programming fluid transport within paper-based devices that enables both acceleration as well as delay of fluid transport without active pumping. Both operations are programmed by carving open channels either longitudinally or perpendicularly to the flow path using a craft-cutting tool equipped with a knife blade. Channels are crafted after mu PADs fabrication enabling the end user to generate patterns of open-channels on demand by carving the porous material of the paper without cutting or removing the paper substrate altogether. Parameters to control the acceleration or delay of flow include the orientation, length, and number of open channels. Using this method, accelerated as well as reduced fluid transport rates were achieved on the same device. This methodology was applied to mu PADs for multiple and time-programmable assays for metal ion determination.