Humanized mice for studying human leukocyte integrins in vivo.
Humanized mice for studying human leukocyte integrins in vivo.
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人源化小鼠用于研究人类白细胞整合蛋白。
DOI：
10.1007/978-1-61779-166-6_30
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Shankar, Premlata
中科院分区：
文献类型：
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作者：
Kim, Sang-Soo;Kumar, Priti;Ye, Chunting;Shankar, Premlata
人源化小鼠最近已成为研究人类造血、免疫相互作用和人类免疫系统疾病的强大翻译动物模型。据报道，在过去的几年里，人源化小鼠技术取得了一些重要的进展，从而改善了植入，提高了人类嵌合体水平，并持续了人类造血。本章描述了生成各种人性化小鼠模型的详细过程，包括HU-PBL、HU-HSC和BLT模型，并讨论了选择适当模型系统的考虑因素。
Humanized mice have recently emerged as powerful translational animal models for studying human hematopoiesis, immune interactions, and diseases of the human immune system. Several important advances in the humanized mouse technology have been reported over the last few years, thereby resulting in improved engraftment, high levels of human chimerism, and sustained human hematopoiesis. This chapter describes the detailed procedures for generating various humanized mouse models including hu-PBL, hu-HSC, and BLT models and discusses considerations for choosing the appropriate model system.