Multifunctional N,S co-doped carbon quantum dots with pH- and thermo-dependent switchable fluorescent properties and highly selective detection of glutathione
Multifunctional N,S co-doped carbon quantum dots with pH- and thermo-dependent switchable fluorescent properties and highly selective detection of glutathione
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多功能 N,S 共掺杂碳量子点，具有 pH 和热依赖性可切换荧光特性以及谷胱甘肽的高选择性检测
DOI：
10.1016/j.carbon.2016.04.003
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发表时间：
2016-08-01
期刊：
影响因子：
10.9
通讯作者：
Liu, Jingquan
中科院分区：
文献类型：
--
作者：
Song, Zhongqian;Quan, Fengyu;Liu, Jingquan
近年来，对环境变化具有响应性的智能多功能材料受到了广泛的关注，因为它们可以应用于生物传感、生物技术和药物输送等领域。本文以L-半胱氨酸和NH3中心点H2O为原料，采用一步水热法在100 ℃下合成了具有pH依赖性和颜色可切换的多功能N，S共掺杂碳量子点（N，S-CQD）。N，S-CQD对pH有响应，并且在碱性和酸性环境之间表现出颜色可切换的荧光性能，具有良好的可逆性。并提出了合理的机制。N，S-CQD具有良好的离子稳定性、生物相容性和温度敏感性。此外，N，S-CQD对其他二巯基化合物如半胱氨酸和同型半胱氨酸中的谷胱甘肽具有很高的选择性，可作为检测谷胱甘肽的传感试剂。由于这些优异的性能，所合成的N，S-CQD在不久的将来具有用于pH传感器、温度传感器和生物工程应用的巨大潜力。(C)2016爱思唯尔有限公司版权所有
Smart and multifunctional materials that can be responsive to the environment change have aroused extensive attention in the last few years, because they can be suitable for various applications, such as biosensing, biotechnology and drug delivery. Herein, multifunctional N,S co-doped carbon quantum dots (N,S-CQDs) with pH dependent and color-switchable fluorescent property were synthesized directly from L-cysteine and NH3 center dot H2O by a one-step hydrothermal route at 100 degrees C. The N,S-CQDs are responsive to pH and exhibit color-switchable fluorescence performance between alkaline and acidic environments with good reversibility. The reasonable mechanism was also proposed. The N,S-CQDs exhibit well ionic stability, good biocompatibility and temperature sensitive fluorescent properties. In addition, the N,SCQDs show a highly selective detection towards glutathione from other bithiols such as Cys and Hcy, which make the N,S-CQDs be sensor reagents for glutathione detection. Given these excellent performances, the as -synthesized N,S-CQDs have great potential to be used for pH sensor, temperature sensor and bioengineering applications in the near future. (C) 2016 Elsevier Ltd. All rights reserved.