Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics.
Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics.
复制标题
通过肽模拟物的 N 末端剪裁揭示金黄色葡萄球菌中有效的泛群群体感应抑制剂。
DOI：
10.1039/d2cc05733f
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Blackwell,HelenE
中科院分区：
文献类型：
--
作者：
Zhao,Ke;Vasquez,JosephK;Blackwell,HelenE
金黄色葡萄球菌使用小肽来评估其群体密度（即群体感应）并调节高细胞数量时的毒力。在这里，我们报告了基于这些天然信号的肽模拟物的设计和合成，这些天然信号强烈阻断金黄色葡萄球菌所有四个特异性组中的这种通讯途径。
Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus.