Quantitative measures of mature neuronal morphology after in utero ethanol exposure.
Quantitative measures of mature neuronal morphology after in utero ethanol exposure.
复制标题
子宫内乙醇暴露后成熟神经元形态的定量测量。
DOI：
--
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Abel El
中科院分区：
文献类型：
--
作者：
Pentney Rj;Cotter;Abel El
树突状网络的新皮质锥体细胞和小脑浦肯野细胞的成熟成年大鼠在子宫内暴露于乙醇进行了分析，从未暴露大鼠的神经元中存在的正常分支模式的定量偏差。成熟的乙醇暴露和对照动物的细胞之间没有显着的定量差异。这些神经元群体的分支树突中没有定量缺陷（在出生时检查时确实表现出乙醇诱导的成熟迟缓）表明，仅限于这些动物的短期妊娠期的乙醇处理可能持续时间不足以在树突的生长模式中产生不可逆的成熟缺陷。
Dendritic networks of neocortical pyramidal cells and cerebellar Purkinje cells of mature adult rats which were exposed to ethanol in utero were analyzed for quantitative deviations from the normal branching patterns present in neurons of unexposed rats. No significant quantitative differences were found between cells of mature ethanol-exposed and control animals. The absence of quantitative deficits in the branching dendrites of these neuronal populations (which do exhibit ethanol-induced maturational retardation when examined at birth) suggests that ethanol treatment confined to the short gestation period in these animals may be of insufficient duration to produce irreversible maturational deficits in the growth pattern of dendrites.