Fatty acid pattern of human prostasome lipid
Fatty acid pattern of human prostasome lipid
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DOI：
10.1006/abbi.1998.0876
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发表时间：
1998-10-15
影响因子：
3.9
通讯作者：
Palmerini, CA
中科院分区：
文献类型：
--
作者：
Arienti, G;Carlini, E;Palmerini, CA
前列腺体是在人类精液中发现的前列腺起源的细胞器。它们的平均直径约为150 nm，表现为脂蛋白膜，包围着组织性较差的物质。它们的脂质组成是特殊的，含有大量的胆固醇和鞘磷脂。另一方面，它们的许多蛋白质具有催化活性并参与免疫反应。在以前的工作中，我们已经表明，前列腺酶体可以融合到精子在微酸性pH值，从而修改精子质膜的组成。本文研究了前列腺体脂质的脂肪酸模式，发现它与精子膜脂质的脂肪酸模式完全不同。多不饱和磷脂酰胆碱常见于精子膜，在前列腺体中较少见。因此，前列腺素体和精子之间的融合应该通过富含胆固醇、鞘磷脂和饱和甘油磷脂来稳定精子质膜。这将防止顶体反应的不合时宜的发生，（C）1998年学术出版社。
Prostasomes are organelles of prostatic origin found in human semen. Their average diameter is about 150 nm and they appear as a lipoprotein membrane surrounding less organized material. Their lipid composition is peculiar, having much cholesterol and sphingomyelin. On the other hand, many of their proteins possess catalytic activity and are involved in the immune response. In previous work, we have shown that prostasomes may fuse to sperm at slightly acidic pH values, thereby modifying the composition of the sperm plasma membrane. In this paper, we examine the fatty acid pattern of prostasome lipid and find that it is completely different from that of sperm membrane lipid. Polyunsaturated phosphatidylcholines, common in sperm membrane, are rare in prostasome. Therefore, the fusion between prostasomes and sperm should stabilize sperm plasma membrane by enriching it in cholesterol, sphingomyelin, and saturated glycerophospholipid. This would prevent the untimely occurrence of the acrosome reaction, (C) 1998 Academic Press.