Treatment continuation of four long-acting antipsychotic medications in the Netherlands and Belgium: A retrospective database study.
Treatment continuation of four long-acting antipsychotic medications in the Netherlands and Belgium: A retrospective database study.
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DOI：
10.1371/journal.pone.0179049
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Mulder CL
中科院分区：
文献类型：
--
作者：
Decuypere F;Sermon J;Geerts P;Denee TR;De Vos C;Malfait B;Lamotte M;Mulder CL
实现更大程度的持续治疗是改善精神分裂症患者治疗结果的关键因素。然而，根据研究设计的不同，报告的治疗持续时间可能存在显着差异。回顾性分析，使用抗精神病药物的患者的治疗持续性总体上仍然较差。本研究旨在根据 QuintilesIMS LRx 数据库（荷兰和比利时零售药房的国家纵向面板处方数据库）记录四种长效注射抗精神病药物之间的治疗持续差异。研究了每月一次的帕潘立酮棕榈酸酯、利培酮微球、氟哌啶醇癸酸酯和奥氮平双羟萘酸酯。这项研究表明，在这两个国家，与利培酮微球（p值<0.01）和氟哌啶醇癸酸酯（p值<0.01）相比，帕潘立酮棕榈酸酯每月一次的治疗持续率显着更高，在荷兰，与奥氮平双羟萘酸盐相比，帕潘立酮棕榈酸酯每月一次的治疗持续率显着更高（p值<0.01），并且总体趋势是与利培酮微球相比，帕潘立酮棕榈酸酯每月一次的治疗持续率更高（p值<0.01）。奥氮平双羟萘酸盐，产自比利时。分析之前未接受过长效抗精神病药物治疗的患者亚组，揭示了之前接受过长效抗精神病药物治疗对继续治疗和后续长效治疗的积极影响。此外，与接受利培酮微球和氟哌啶醇癸酸酯治疗的患者相比，每月一次接受帕潘立酮棕榈酸酯治疗的患者重新开始指数治疗的可能性更高。使用的数据源和定义的方法首次确保了在非干预性研究设计中对所研究的四种长效注射抗精神病药物的治疗持续性进行比较。
Achieving greater continuation of treatment is a key element to improve treatment outcomes in schizophrenia patients. However, reported treatment continuation can differ markedly depending on the study design. In a retrospective setting, treatment continuation remains overall poor among patients using antipsychotics. This study aimed to document the difference in treatment continuation between four long-acting injectable antipsychotics based on the QuintilesIMS LRx databases, national, longitudinal, panel based prescription databases of retail pharmacies, in the Netherlands and Belgium. Paliperidone palmitate once monthly, risperidone microspheres, haloperidol decanoate, and olanzapine pamoate were studied. This study demonstrated significantly higher treatment continuation of paliperidone palmitate once monthly compared to risperidone microspheres (p-value<0,01) and haloperidol decanoate (p-value<0,01) in both countries, a significantly higher treatment continuation of paliperidone palmitate once monthly compared to olanzapine pamoate in the Netherlands (p-value<0,01), and a general trend towards better treatment continuation versus olanzapine pamoate in Belgium. Analysing the subgroup of patients without previous exposure to long-acting antipsychotic treatment revealed the positive impact of previous exposure on treatment continuation with a subsequent long acting treatment. Additionally, the probability of restarting the index therapy was higher among patients treated with paliperidone palmitate once monthly compared to patients treated with risperidone microspheres and haloperidol decanoate. The data source used and the methodology defined ensured for the first time a comparison of treatment continuation in a non-interventional study design for the four long-acting injectable antipsychotics studied.