LOCAL ANTINOCICEPTIVE AND TOPICAL ANTI-INFLAMMATORY EFFECTS OF PROPYL GALLATE IN RODENTS
LOCAL ANTINOCICEPTIVE AND TOPICAL ANTI-INFLAMMATORY EFFECTS OF PROPYL GALLATE IN RODENTS
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DOI：
10.1111/j.1476-5381.1976.tb08626.x
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发表时间：
1976-01-01
影响因子：
7.3
通讯作者：
SCHNEIDER, C
中科院分区：
文献类型：
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作者：
MCDONALDGIBSON, WJ;SAEED, SA;SCHNEIDER, C
1 与多种抗炎、镇痛、局部麻醉和抗氧化药物一样，没食子酸丙酯在体外可抑制公牛精囊前列腺素合成酶从花生四烯酸生物合成前列腺素 E2 和 F2α。 2 与镇痛药一样，没食子酸丙酯可降低花生四烯酸、乙酰胆碱或乙酸引起小鼠腹部收缩的能力。 3 使用一种评估抗炎活性的新方法，我们证明了在紫外线治疗前皮下注射阿司匹林或吲哚美辛的有效性。豚鼠耳朵的照射、局部涂抹防晒剂的预防作用以及照射后使用丁苯哌酸和没食子酸丙酯的治疗价值。
1 In common with several anti-inflammatory, analgesic, local anaesthetic and antioxidant drugs, propyl gallate in vitro inhibited the biosynthesis of prostaglandin E2 and F2alpha from arachidonic acid by a prostaglandin synthetase from bull seminal vesicles. 2 In common with analgesic drugs, propyl gallate reduced the ability of arachidonic acid, acetylcholine or acetic acid to cause abdominal constriction in mice. 3 Using a new method for evaluating anti-inflammatory activity, we demonstrated the effectiveness of aspirin or indomethacin given subcuteneously before u.v. irradiation of guinea-pig ears, the prophylactic action of topically applied sunscreen agents and the therapeutic value of bufexamac and propyl gallate applied after irradiation.