Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers.
Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers.
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DOI：
10.4143/crt.2005.37.2.98
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发表时间：
2005-04-01
影响因子：
4.6
通讯作者：
Choe, Gheeyoung
中科院分区：
文献类型：
--
作者：
Lee, Hye Seung;Yang, Han-Kwang;Choe, Gheeyoung
目的：DNA-PKcs是DNA修复基因之一。最近发现DNA-PKcs基因敲除小鼠肠黏膜的增殖和不典型增生以及异常隐窝灶的产生，提示DNA-PKcs在肿瘤发生中的抑制作用。材料和方法：检测279例胃癌组织中DNA-PKcs的表达情况，以探讨其临床病理特征与胃癌患者生存的可能关系。结果：在279例胃癌中，63例(22.6%)DNA-PKcs蛋白表达缺失。DNA-PKcs表达缺失与晚期癌症显著相关(p
PURPOSE: DNA-PKcs is one of the DNA repair genes. It was recently found that hyperplasia and dysplasia of the intestinal mucosa and the production of aberrant crypt foci were developed in DNA-PKcs-null mice, and this suggests a suppressive role for DNA-PKcs in tumorigenesis.MATERIALS AND METHODS: To investigate the possible relationship between the clinico-pathologic characteristics and the survival of gastric cancer patients, the expression status of DNA-PKcs was determined in 279 consecutive gastric cancers. Immunohistochemical analysis was performed to evaluate the expression levels of DNA-PKcs protein by using the tissue array method.RESULTS: Out of 279 consecutive gastric cancers, 63 cases (22.6%) showed the loss of DNA-PKcs expression. The loss of DNA-PKcs expression was significantly associated with advanced cancer (p