Dissociable hippocampal and amygdalar D1-like receptor contribution to discriminated Pavlovian conditioned approach learning.
Dissociable hippocampal and amygdalar D1-like receptor contribution to discriminated Pavlovian conditioned approach learning.
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DOI：
10.1016/j.bbr.2015.11.034
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发表时间：
2016-02-15
影响因子：
2.7
通讯作者：
Ryals C
中科院分区：
文献类型：
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作者：
Andrzejewski ME;Ryals C
巴甫洛夫条件反射是与奖励相关的行为适应的一种基本形式。中脑边缘多巴胺系统被广泛认为介导奖励相关学习的关键方面。例如，积极强化操作行为的初始习得需要激活杏仁核基底外侧（BLA）、杏仁核中央核（CeA）和腹侧下带（vSUB）的多巴胺（DA） D1受体（D1R）。然而，这些区域的D1R激活在食欲、非药物相关的巴甫洛夫学习中的作用目前尚不清楚。在单独的实验中，将d1样受体拮抗剂SCH-23390（每侧3.0 nmol/0.5 μL）微量输注到杏仁核和耻骨下，然后进行区分巴普洛夫条件方法（dPCA）训练。这三种结构中的d1样拮抗均损害了辨别方法的习得，但在条件反射渐近后对表现没有影响。此外，还获得了三种结构中d1样拮抗对区分反应组分的解离效应。最后，药物治疗组缺乏潜在抑制可能阐明d1样蛋白在奖励相关的巴甫洛夫条件反射中的作用。目前的数据表明，杏仁核和海马体中的D1受体在学习条件刺激的意义中起作用，但在条件反应的表达中不起作用。
Pavlovian conditioning is an elementary form of reward-related behavioral adaptation. The mesolimbic dopamine system is widely considered to mediate critical aspects of reward-related learning. For example, initial acquisition of positively-reinforced operant behavior requires dopamine (DA) D1 receptor (D1R) activation in the basolateral amygdala (BLA), central nucleus of the amygdala (CeA), and the ventral subiculum (vSUB). However, the role of D1R activation in these areas on appetitive, non-drug-related, Pavlovian learning is not currently known. In separate experiments, microinfusions of the D1-like receptor antagonist SCH-23390 (3.0 nmol/0.5 μL per side) into the amygdala and subiculum preceded discriminated Pavlovian conditioned approach (dPCA) training sessions. D1-like antagonism in all three structures impaired the acquisition of discriminated approach, but had no effect on performance after conditioning was asymptotic. Moreover, dissociable effects of D1-like antagonism in the three structures on components of discriminated responding were obtained. Lastly, the lack of latent inhibition in drug-treated groups may elucidate the role of D1-like in reward-related Pavlovian conditioning. The present data suggest a role for the D1 receptors in the amygdala and hippocampus in learning the significance of conditional stimuli, but not in the expression of conditional responses.