Magnesium and calcium in drinking water and the risk of death from esophageal cancer.
Magnesium and calcium in drinking water and the risk of death from esophageal cancer.
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DOI：
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发表时间：
2002-12
影响因子：
3.2
通讯作者：
Chun-Yuh Yang;H. Chiu;S. Tsai;Trong-Neng Wu;Chin-Ching Chang
中科院分区：
文献类型：
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作者：
Chun-Yuh Yang;H. Chiu;S. Tsai;Trong-Neng Wu;Chin-Ching Chang
在台湾进行的一项配对病例对照研究中，调查了食管癌风险与市政供水饮用水中钙和镁水平之间的可能关联。本研究以1991年至2000年台湾地区所有符合条件的肺癌死亡者（2204例）为研究对象，并以其他死因死亡者（2204例对照）为研究对象，测定其饮用水中钙、镁的含量。台湾饮用水中钙和镁含量的数据来自台湾自来水公司（TWSC）。对照组由死于其他原因的人组成，对照组按性别、出生年份和死亡年份与病例配对。与镁水平低于7.0 mg/l的人群相比，水镁水平在7.3和14.0 mg/l之间的人群的校正比值比（95%置信区间（CI））为0.75（0.62-0.91），镁水平在14.3 mg/l或以上的人群为0.71（0.57-0.88）。饮用水中钙水平与食管癌之间关系的校正比值比与1之间没有统计学显著差异。本研究的结果表明，有一个显着的趋势，食管癌的风险降低与镁水平的饮用水。
The possible association between the risk of esophageal cancer and the levels of calcium and magnesium in drinking water from municipal supplies was investigated in a matched case-control study in Taiwan. All eligible esophageal-cancer deaths (2204 cases) of Taiwan residents from 1991 through 2000 were compared with a sample of deaths from other causes (2204 controls), and the levels of calcium and magnesium in the drinking water of these residents were determined. Data on calcium and magnesium levels in drinking water throughout Taiwan were obtained from the Taiwan Water Supply Corporation (TWSC). The control group consisted of people who died from other causes, and the controls were pair-matched to the cases by gender, year of birth, and year of death. Compared to those with magnesium levels below 7.0 mg/l, the adjusted odd ratios (95 per cent confidence interval (CI)) were 0.75 (0.62-0.91) for the group with water magnesium levels between 7.3 and 14.0 mg/l and 0.71 (0.57-0.88) for the group with magnesium levels of 14.3 mg/l or more. The adjusted odd ratios for the relationship between calcium levels in drinking water and esophageal cancer were not statistically significantly different from 1. The results of the present study show that there is a significant trend toward a decreased risk of esophageal cancer with increasing magnesium level in drinking water.