SEROLOGICAL DIFFERENCES BETWEEN ACUTE AND CHRONIC SCHISTOSOMIASIS MANSONI DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
SEROLOGICAL DIFFERENCES BETWEEN ACUTE AND CHRONIC SCHISTOSOMIASIS MANSONI DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
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DOI：
10.4269/ajtmh.1979.28.87
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
CHEEVER, AW
中科院分区：
文献类型：
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作者：
LUNDE, MN;OTTESEN, EA;CHEEVER, AW
采用ELISA技术，使用从虫卵、尾蚴和蠕虫制备的抗原[Ag]，对急性和慢性曼氏血吸虫病患者和实验室感染[Cercopithecus]猴的血清进行了检查。急性血吸虫病患者和2个月猴的血清。感染后血清对尾蚴抗原的反应比对成虫抗原的反应强，而慢性血吸虫病患者和感染时间超过4个月的猴血清的反应则弱于成虫抗原。对成虫抗原的反应更强。这些对Ag的不同反应在血清学上区分了急性和慢性病毒性感染。
Sera from patients with acute and chronic schistosomiasis mansoni and from laboratory-infected [Cercopithecus] monkeys were examined by an ELIS A technique using antigens [Ag] prepared from eggs, cercariae, and adult worms. Sera from patients with acute schistosomiasis and from monkeys 2 mo. post-infection reacted more positively to cercarial Ag than to adult worm Ag whereas sera from patients with chronic schistosomiasis and monkeys infected for longer than 4 mo. reacted more positively to adult worm Ag. These differential responses to Ag serologically differentiated between acute and chronic schistosome infections.