Percutaneous MR imaging-guided radiofrequency interstitial thermal ablation of tongue base in porcine models: implications for obstructive sleep apnea syndrome.
Percutaneous MR imaging-guided radiofrequency interstitial thermal ablation of tongue base in porcine models: implications for obstructive sleep apnea syndrome.
复制标题
经皮 MR 成像引导猪模型舌根射频间质热消融：对阻塞性睡眠呼吸暂停综合征的影响。
DOI：
10.1148/radiol.2302021056
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Strauss,Melvin
中科院分区：
文献类型：
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作者：
Nour,SherifGamal;Lewin,JonathanS;Gutman,Michael;Hillenbrand,Claudia;Wacker,FrankK;Wong,JohnW;Mitchell,IanC;Armstrong,CharlesB;Hashim,MufaddalM;Duerk,JeffreyL;Strauss,Melvin
目的：测试的可行性和安全性的经皮磁共振（MR）成像引导技术射频（RF）间质热消融的舌根和相关的MR外观诱导的热损伤与组织病理学发现在猪在急性和慢性猪models.MATERIALS和方法：1厘米尖端射频电极插入到舌perendum在10头猪与0.2 T实时MR引导。射频电极沿舌动脉之间的中线向上推进，并在舌粘膜附近停止。在90°C ± 2下进行RF间质热消融，持续10分钟。用1.5 T MR成像仪获得消融后图像。5头猪立即处死（急性模型），而5头猪在处死前随访1个月（慢性模型）。在慢性组中，在射频消融之前，在MR成像引导下将MR兼容的基准线圈插入舌部。采集舌进行组织病理学分析。将射频消融后即刻、2周和1个月获得的图像的平均热损伤体积与Studentt检验进行比较。病变直径在大体病理分析和相应的直径与每个脉冲sequence.Results：成功的MR成像引导电极定位实现在所有程序中没有内或术后并发症，因为有很高的血管的显着性和组织对比度的类间相关系数。两组中所有序列的热损伤均呈低信号，周围边缘呈高信号。在病理分析中，急性病变表现为充血边缘包围的苍白坏死区，而慢性病变表现为进行性周向纤维化和显著的体积缩小（P<0.01）。在大体病理分析中测量的热损伤直径与在短反转时间反转-恢复图像上测量的相应直径最一致（类间相关系数= 0.85）。结论：本研究的结果证明了舌根的MR成像引导的RF间质热消融是可行的和安全的，并说明了与诱导的热损伤的产生和演变相关的成像和病理现象。© RSNA，2004
PURPOSE:To test the feasibility and safety of a percutaneous magnetic resonance (MR) imaging–guided technique for radiofrequency (RF) interstitial thermal ablation of the tongue base and to correlate MR appearance of induced thermal lesions with histopathologic findings in pigs in acute and chronic porcine models.MATERIALS AND METHODS:A 1-cm-tip RF electrode was inserted percutaneously into the tongue in 10 pigs with 0.2-T real-time MR guidance. The RF electrode was advanced up the midline between lingual arteries and stopped short of tongue mucosa. RF interstitial thermal ablation was performed at 90°C ± 2 and lasted 10 minutes. Postablation images were obtained with a 1.5-T MR imager. Five pigs were sacrificed immediately (acute model), while five were followed up for 1 month (chronic model) before they were sacrificed. MR-compatible fiducial coils were inserted into tongues with MR imaging guidance prior to RF ablation in the chronic group. Tongues were harvested for histopathologic analysis. Mean thermal lesion volume was compared with the Studentttest on images obtained immediately, 2 weeks, and 1 month after RF ablation. Interclass correlation coefficients of lesion diameters at gross pathologic analysis and corresponding diameters with each pulse sequence were calculated.RESULTS:Successful MR imaging–guided electrode positioning was achieved in all procedures without intra- or postprocedure complications because there was high vascular conspicuity and tissue contrast. Thermal lesions appeared hypointense with hyperintense surrounding rims with all sequences in both groups. At pathologic analysis, acute lesions appeared as pale necrotic areas surrounded by hyperemic rims, while chronic lesions demonstrated progressive circumferential fibrosis and significant volume shrinkage (P< .01). Thermal lesion diameters measured at gross pathologic analysis best agreed with corresponding diameters measured on short inversion time inversion-recovery images (interclass correlation coefficient = 0.85).CONCLUSION:The results of this investigation demonstrate MR imaging–guided RF interstitial thermal ablation of the tongue base is feasible and safe and illustrate imaging and pathologic phenomena associated with creation and evolution of the induced thermal lesions.© RSNA, 2004