Multifunctional Nanobiomaterials for Neural Interfaces
Multifunctional Nanobiomaterials for Neural Interfaces
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DOI：
10.1002/adfm.200801473
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发表时间：
2009-02-24
影响因子：
19
通讯作者：
Martin, David C.
中科院分区：
文献类型：
--
作者：
Abidian, Mohammad Reza;Martin, David C.
神经电极被设计成与神经系统接口，并为神经假体提供控制信号。然而，健壮和可靠的慢性记录和刺激仍然是神经电极面临的挑战。本文报道了一种制备柔软、低阻抗、高电荷密度、可控制释放的纳米生物材料的新方法，该材料可用于神经微电极的表面修饰，以稳定电极/组织界面。该制造工艺包括：电纺含有抗炎药物的生物可降解纳米纤维，将这些纳米纤维包裹；通过海藻酸水凝胶层，然后在电纺的载药纳米纤维周围进行导电聚合物的电化学聚合，以形成纳米管，并在海藻酸水凝胶支架内形成云状纳米结构。三维导电聚合物纳米结构显著降低了电极阻抗，提高了充电容量密度。地塞米松的释放曲线显示，海藻酸盐水凝胶涂层减缓了药物的释放，显著降低了爆裂效应。这些多功能材料有望用于生物医学设备中的各种电极/组织界面。
Neural electrodes are designed to interface with the nervous system and provide control signals for neural prostheses. However, robust and reliable chronic recording and stimulation remains a challenge for neural electrodes. Here, a novel method for the fabrication of soft, low impedance, high charge density, and controlled releasing nanobiomaterials that can be used for the surface modification of neural microelectrodes to stabilize the electrode/tissue interface is reported. The fabrication process includes electrospinning of anti-inflammatory drug-incorporated biodegradable nanofibers, encapsulation of these nanofibers; by an alginate hydrogel layer, followed by electrochemical polymerization of conducting polymers around the electrospun drug-loaded nanofibers to form nanotubes and within the alginate hydrogel scaffold to form cloud-like nanostructures. The three-dimensional conducting polymer nanostructures significantly decrease the electrode impedance and increase the charge capacity density. Dexamethasone release profiles show that the alginate hydrogel coating slows down the release of the drug, significantly reducing the burst effect. These multifunctional materials are expected to be of interest for a variety of electrode/tissue interfaces in biomedical devices.