Detection of Serum Interleukin-6/10/18 Levels in Sepsis and Its Clinical Significance
Detection of Serum Interleukin-6/10/18 Levels in Sepsis and Its Clinical Significance
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DOI：
10.1002/jcla.21977
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发表时间：
2016-11-01
影响因子：
2.7
通讯作者：
Zhang, Hui
中科院分区：
文献类型：
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作者：
Feng, Mingchen;Sun, Tingting;Zhang, Hui
目的探讨血清IL-6/10/18水平在脓毒症中的临床意义。方法选择66例脓毒症患者作为病例组。另外，选取42名健康成人作为对照组。ELISA法检测血清IL-6/10/18水平，ROC法评价IL-6/10/18在脓毒症中的诊断价值。结果脓毒症组患者心率、呼吸频率、WBC计数、APACHEⅱ评分均显著高于对照组，且轻度脓毒症组、重度脓毒症组、脓毒症休克组患者上述指标依次升高（校正后均P < 0.05）。脓毒症患者血清IL-6/18水平显著高于对照组，且轻度脓毒症组、重度脓毒症组、脓毒症休克组血清IL-6/18水平依次升高，差异均有统计学意义（P < 0.05）。各组血清IL-10水平差异无统计学意义（P < 0.05）。IL-6和IL-18的分界点分别为109.19 pg/ml（敏感性94.4%，特异性83.3%）和116.01 pg/ml（敏感性77.8%，特异性83.3%）。血清IL-6水平与APACHEⅱ评分和心率呈正相关（P < 0.001）。结论脓毒症患者血清IL-6/8水平升高。此外，IL-6比IL-18具有更高的敏感性。血清IL-6水平与APACHE II评分和心率呈正相关，提示IL-6可作为脓毒症的潜在生物标志物。
ObjectiveTo explore the clinical significance of serum levels of IL-6/10/18 in sepsis.MethodsSixty-six patients with sepsis were selected to be the case group. Additionally, 42 healthy adults were selected to be the control group. ELISA was used to measure the serum levels of IL-6/10/18, and ROC was utilized to evaluate the diagnostic values of IL-6/10/18 in sepsis.ResultsThe heart rate, respiratory rate, WBC count and APACHE II score in the sepsis group were significantly higher than those in the control group, and these indexes were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (all P < 0.05 after correction). The serum IL-6/18 levels in sepsis patients were significantly higher than those in the control group, and both of the levels were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (both P < 0.05). However, no significant difference was found in serum IL-10 level between groups (P > 0.05). The cut-off points of IL-6 and IL-18 were 109.19 pg/ml (sensitivity: 94.4%; specificity: 83.3%) and 116.01 pg/ml (sensitivity: 77.8%; specificity: 83.3%), respectively. Serum IL-6 levels were positively correlated with the APACHE II score and heart rate (both P < 0.001).ConclusionSerum levels of IL-6/8 are up-regulated in sepsis patients. Additionally, IL-6 has a greater sensitivity than IL-18. Serum IL-6 levels were positively correlated with the APACHE II score and heart rate, indicating that IL-6 could be used as a potential biomarker for sepsis.