Osteoinduction by biomaterials - Physicochemical and structural influences
Osteoinduction by biomaterials - Physicochemical and structural influences
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DOI：
10.1002/jbm.a.30712
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发表时间：
2006-06-15
影响因子：
4.9
通讯作者：
de Groot, K
中科院分区：
文献类型：
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作者：
Habibovic, P;Sees, TM;de Groot, K
在过去的十年中，许多研究人员已经证明生物材料的骨融合是一种真实的现象。然而，这种现象的确切机制在很大程度上仍然是未知的。这项在山羊体内进行的研究是为了深入了解生物材料诱导成骨现象的过程，主要有四个目标：(i)进一步研究物理化学性质和结构对生物材料骨诱导电位的影响，（ii）研究植入物大小对诱导骨数量的影响，（iii）研究植入部位依赖性，（iv）研究植入后材料表面发生的变化。肌肉内植入四种不同的双相磷酸钙陶瓷，包括羟基磷灰石、β -磷酸三钙和碳化磷灰石陶瓷，表明对于最大的骨诱导电位，每种材料类型都有一个最佳比表面积。结果表明，当种植体尺寸减小一半时，诱导骨的相对数量明显减少。此外，皮下植入没有引起任何动物的异位骨形成，而大多数动物的骨是肌内诱导的。对扩散室内皮下植入后材料表面的分析表明，增加的比表面积导致更多的表面反应性，这被认为是生物材料的骨诱导性所必需的。(c) 2006 Wiley期刊公司
Osteoincluction by biomaterials has been shown to be a real phenomenon by many investigators in the last decade. The exact mechanism of this phenomenon is, however, still largely unknown. This in vivo study in goats was performed to get insight into processes governing the phenomenon of osteoinduction by biomaterials and had four main goals: (i) to further investigate the influence of physicochemical properties and structure on biomaterial osteoinductive potential, (ii) to investigate the influence of implant size on the amount of induced bone, (iii) to investigate implantation site dependence, and (iv) to investigate changes occurring on the surface of the material after implantation. Intramuscular implantations of four different biphasic calcium phosphate ceramics, consisting of hydroxyapatite and beta-tricalcium phosphate and a carbonated apatite ceramic, indicated that, for a maximal osteoinductive potential, there is an optimal specific surface area for each material type. It was further shown that a decrease of the implant size with a half significantly decreased the relative amount of induced bone. In addition, subcutaneous implantation did not give rise to ectopic bone formation in any of the animals, while bone was induced in most animals intramuscularly. Analysis of the surfaces of the materials after subcutaneous implantation inside diffusion chambers indicated that the increased specific surface area leads to more surface reactivity, which is hypothesized to be essential for osteoinductivity by biomaterials. (c) 2006 Wiley Periodicals, Inc.