Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury.
Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury.
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DOI：
10.1097/mot.0b013e328342542e
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发表时间：
2011-02
影响因子：
2.2
通讯作者：
Coito AJ
中科院分区：
文献类型：
--
作者：
Coito AJ
肝脏缺血再灌注损伤（IRI）与白细胞募集和随后的细胞因子和自由基的释放有关，仍然是器官移植的重要并发症。这篇综述的目的是引起人们对肝脏IRI炎症刺激部位白细胞募集机制的认识。白细胞穿越内皮和细胞外基质（ECM）屏障依赖于粘附事件以及局灶性基质降解机制。虽然粘附分子通过提供白细胞附着于血管内皮而成功促进白细胞迁移是至关重要的，但基质金属蛋白酶（MMP）对于促进白细胞移动穿过血管屏障是重要的。在不同的基质金属蛋白酶，基质金属蛋白酶-9，诱导明胶酶表达的白细胞在肝IRI，正在成为一个重要的介导白细胞交通到发炎的肝脏。人们普遍认为，白细胞募集的分子机制的理解将导致新的肝IRI和肝移植的靶向治疗方法的发展。在这里，我们审查机制的白细胞交通在肝脏IRI和一些蛋白质的作用，被认为是重要的这一进程。
Hepatic ischemia reperfusion injury (IRI) linked to leukocyte recruitment and subsequent release of cytokines and free radicals remains a significant complication in organ transplantation. The aim of this review is to bring attention to advances made in our understanding of the mechanisms of leukocyte recruitment to sites of inflammatory stimulation in liver IRI. Leukocyte transmigration across endothelial and extracellular matrix (ECM) barriers is dependent on adhesive events, as well as on focal matrix degradation mechanisms. While adhesion molecules are critical for the successful promotion of leukocyte transmigration by providing leukocyte attachment to the vascular endothelium, matrix metalloproteinases (MMPs) are important for facilitating leukocyte movement across vascular barriers. Among different MMPs, MMP-9, an inducible gelatinase expressed by leukocytes during hepatic IRI, is emerging as an important mediator of leukocyte traffic to inflamed liver. It is generally accepted that the understanding of the molecular mechanisms involved in leukocyte recruitment will lead to the development of novel targeted therapeutic approaches for hepatic IRI and liver transplantation. Here, we review mechanisms of leukocyte traffic in liver IRI and the role of some of the proteins that are thought to be important for this process.