Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study.
Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study.
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维生素 B12 替代疗法对血清 B12 水平低的痴呆症的认知和精神影响：一项疗养院研究。
DOI：
10.1017/s1041610208007904
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发表时间：
2009
影响因子：
7
通讯作者：
Siegal,AlanP
中科院分区：
文献类型：
--
作者：
vanDyck,ChristopherH;Lyness,JeffreyM;Rohrbaugh,RobertM;Siegal,AlanP
本研究的目的是确定B12替代是否会改善老年痴呆和低血清B12水平受试者的认知和精神症状。方法采用盲法评价血清B12水平低（<250 pg/mL）的实验组（n = 28）和血清B12水平正常（>300 pg/mL）的对照组（n = 28），实验组接受肌肉注射（IM） B12替代疗法。所有受试者在基线、8周和16周使用痴呆评定量表、简短精神病学评定量表和老年抑郁量表进行评估。结果虽然B12替代对血液和代谢参数有显著改善，但对认知和精神变量没有显著影响。少数受试者表现出显著的个体治疗反应；然而，从统计上看，这些情况并不比正常B12组更频繁。这些结果表明，对于绝大多数血清B12水平较低的老年痴呆患者，补充B12不太可能改善认知或精神症状。
BackgroundThe aim of this study is to determine whether B12 replacement would ameliorate cognitive and psychiatric symptoms in elderly subjects with dementia and low serum B12 levels.MethodsA test group (n = 28) of nursing home residents with low serum B12 levels (<250 pg/mL) and a matched comparison group (n = 28) with normal serum B12 levels (>300 pg/mL) were evaluated by blinded raters while the test group received intramuscular (IM) B12 replacement therapy. All subjects were assessed at baseline, 8 weeks, and 16 weeks with the Dementia Rating Scale, Brief Psychiatric Rating Scale, and Geriatric Depression Scale.ResultsAlthough B12 replacement produced significant improvement in hematologic and metabolic parameters, it yielded no significant effect on cognitive or psychiatric variables. A few subjects evidenced notable individual treatment responses; however, these were not statistically more frequent than in the normal B12 group.ConclusionsThese results suggest that B12 replacement is unlikely to benefit cognitive or psychiatric symptoms in the vast majority of elderly dementia patients with low serum B12 levels.