Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.
Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.
复制标题
两种候选亚单位疫苗抗原的组合可在小鼠中引发对蓖麻毒素和炭疽毒素的保护性免疫。
DOI：
10.1016/j.vaccine.2014.11.036
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发表时间：
2015
期刊：
影响因子：
5.5
通讯作者：
Mantis,NicholasJ
中科院分区：
文献类型：
--
作者：
Vance,DavidJ;Rong,Yinghui;Brey3rd,RobertN;Mantis,NicholasJ
为了开发生物防御组合疫苗，我们评估了与炭疽保护性抗原 DNI 联合使用的蓖麻毒素亚基抗原 RiVax。该组合产生了高终点滴度抗体反应、中和抗体以及针对蓖麻毒素和炭疽致命毒素的保护性免疫力。这是一种天然的组合疫苗，因为两种抗原都是重组亚基蛋白，可以给予相同的目标人群。
In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.