The Decision Value Computations in the vmPFC and Striatum Use a Relative Value Code That is Guided by Visual Attention
The Decision Value Computations in the vmPFC and Striatum Use a Relative Value Code That is Guided by Visual Attention
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DOI：
10.1523/jneurosci.1246-11.2011
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发表时间：
2011-09-14
影响因子：
5.3
通讯作者：
Rangel, Antonio
中科院分区：
文献类型：
--
作者：
Lim, Seung-Lark;O'Doherty, John P.;Rangel, Antonio
在行为神经科学中，越来越多的人认为，大脑在做出简单的选择时，首先会给所考虑的选项赋值，然后再进行比较。两个重要的悬而未决的问题是，大脑是编码绝对价值信号还是相对价值信号，以及注意力在这些计算中可能扮演什么角色。我们利用人类功能磁共振成像（fMRI）实验研究了这些问题，该实验采用二元选择任务，对两种刺激的注视进行外源性操纵，以控制视觉注意在估值计算中的作用。我们发现腹内侧前额叶皮层和腹侧纹状体编码注视依赖的相对价值信号：这些区域的活动与被关注和未被关注的物品之间的价值差异相关。这些由注意力调节的相对值信号可以作为比较系统的输入，用于做出选择。
There is a growing consensus in behavioral neuroscience that the brain makes simple choices by first assigning a value to the options under consideration and then comparing them. Two important open questions are whether the brain encodes absolute or relative value signals, and what role attention might play in these computations. We investigated these questions using a human fMRI experiment with a binary choice task in which the fixations to both stimuli were exogenously manipulated to control for the role of visual attention in the valuation computation. We found that the ventromedial prefrontal cortex and the ventral striatum encoded fixation-dependent relative value signals: activity in these areas correlated with the difference in value between the attended and the unattended items. These attention-modulated relative value signals might serve as the input of a comparator system that is used to make a choice.