Pineal indole metabolism in the mouse
Pineal indole metabolism in the mouse
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DOI：
10.1016/0006-8993(87)91505-8
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发表时间：
1987-07
期刊：
影响因子：
2.9
通讯作者：
S. Ebihara;D. Hudson;T. Marks;M. Menaker
中科院分区：
文献类型：
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作者：
S. Ebihara;D. Hudson;T. Marks;M. Menaker
本文测定了几种小鼠松果体中褪黑素N-乙酰转移酶（SNAT）和羟吲哚-O-甲基转移酶（HIOMT）的活性以及松果体中5-羟色胺（5-HT）和N-乙酰5-羟色胺（NAS）的含量，以比较它们之间褪黑素的合成途径。在所检测的品系中，C57 BL/6 J、AKR/J、BALB/c、NZB/BLNJ和野生小鼠中，只有野生小鼠合成松果体褪黑素。野生小鼠具有高活性的SNAT和HIOMT; NZB具有SNAT活性但不具有HIOMT;其他三个品系既不具有SNAT也不具有HIOMT;野生小鼠的SNAT活性显示出明显的日节律，但HIOMT活性没有显示出任何显著的日变化。野生小鼠和NZB小鼠松果体5-HT含量白天高于夜间，而C57 BL和AKR小鼠松果体5-HT含量夜间高于白天。正如预期的那样，在野生小鼠和NZB小鼠中发现了NAS。
The activity of two pineal enzymes serotoninN-acetyltransferase (SNAT) and hydroxyindole-O-methyltransferase, (HIOMT) and the pineal content of serotonin (5-HT) andN-acetylserotonin (NAS) were measured in several strains of mice (Mus domesticus) in order to compare melatonin synthetic pathways among them. Of the strains we examined, C57BL/6J, AKR/J, BALB/c, NZB/BLNJ and wild mice, only wild mice synthesize pineal melatonin. Wild mice had high activity of both SNAT and HIOMT; NZB had SNAT activity but did not have HIOMT; the three other strains had neither SNAT nor HIOMT; the activity of SNAT in wild mice showed a clear daily rhythm but HIOMT activity did not show any significant daily changes. The pineal content of 5-HT in wild and NZB mice was higher during the day than during the night, however in C57BL and AKR, 5-HT levels were higher during the night than during the day. As expected NAS was found in wild and NZB mice.