Distinguishing subregions of the human MT plus complex using visual fields and pursuit eye movements
Distinguishing subregions of the human MT plus complex using visual fields and pursuit eye movements
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DOI：
10.1152/jn.2001.86.4.1991
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发表时间：
2001-10-01
影响因子：
2.5
通讯作者：
Vilis, T
中科院分区：
文献类型：
--
作者：
Dukelow, SP;DeSouza, JFX;Vilis, T
在人类中，功能成像研究已经证明，在颞下沟升肢中存在猕猴运动复合体的同源物 MT+ [建议包含颞中叶 (MT) 和内侧上颞叶 (MST)]。在猕猴中，运动敏感区 MT 和 MST 在颞上沟中相邻。电生理学研究表明，MT 感受野主要编码对侧视野，而 MST 背侧 (MSTd) 感受野则很好地延伸到同侧视野。此外，猕猴 MST 已被证明可以接收视网膜外平滑追踪眼球运动信号，而 MT 则不能。我们使用功能磁共振成像 (fMRI) 和在猴子中观察到的神经特性来区分假定的人类区域 MT 和 MST。置于整个视野或仅对侧视野的光流刺激在我们的受试者中产生了一大群功能激活，这与之前关于人类区域 MT+ 的报告一致。仅限于周边视网膜的同侧视流刺激仅在 MT+ 复合体的前分段产生激活，可能对应于假定的 MSTd。在视觉追踪单个目标的过程中，MT+复合体的很大一部分被激活。然而，在非视觉追踪过程中，只有 MT+ 复合体的前外侧部分被激活。 MT+簇的这个分段可以对应于假定的MST1（横向）。总之，我们观察到人类 MT+ 复合物的三个不同的子区域，它们的排列方式与猴子中相似。
In humans, functional imaging studies have demonstrated a homologue of the macaque motion complex, MT+ [suggested to contain both middle temporal (MT) and medial superior temporal (MST)], in the ascending limb of the inferior temporal sulcus. In the macaque monkey, motion-sensitive areas MT and MST are adjacent in the superior temporal sulcus. Electrophysiological research has demonstrated that while MT receptive fields primarily encode the contralateral visual field, MST dorsal (MSTd) receptive fields extend well into the ipsilateral visual field. Additionally, macaque MST has been shown to receive extraretinal smooth-pursuit eye-movement signals, whereas MT does not. We used functional magnetic resonance imaging (fMRI) and the neural properties that had been observed in monkeys to distinguish putative human areas MT from MST. Optic flow stimuli placed in the full field, or contralateral field only, produced a large cluster of functional activation in our subjects consistent with previous reports of human area MT+. Ipsilateral optic flow stimuli limited to the peripheral retina produced activation only in an anterior subsection of the MT+ complex, likely corresponding to putative MSTd. During visual pursuit of a single target, a large portion of the MT+ complex was activated. However, during nonvisual pursuit, only the anterolateral portion of the MT+ complex was activated. This subsection of the MT+ cluster could correspond to putative MSTl (lateral). In summary, we observed three distinct subregions of the human MT+ complex that were arranged in a manner similar to that seen in the monkey.