PRE-BOTZINGER COMPLEX - A BRAIN-STEM REGION THAT MAY GENERATE RESPIRATORY RHYTHM IN MAMMALS
PRE-BOTZINGER COMPLEX - A BRAIN-STEM REGION THAT MAY GENERATE RESPIRATORY RHYTHM IN MAMMALS
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DOI：
10.1126/science.1683005
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发表时间：
1991-11-01
期刊：
影响因子：
56.9
通讯作者：
FELDMAN, JL
中科院分区：
文献类型：
--
作者：
SMITH, JC;ELLENBERGER, HH;FELDMAN, JL
哺乳动物产生呼吸节奏的神经元的位置尚不清楚。通过体外新生大鼠脑干的显微切片，鉴定了髓质腹侧（前波青格复合体）的有限区域，该区域含有节律发生所必需的神经元。通过仅去除该区域来消除节奏产生。含有前波青格复合体的髓质切片产生与呼吸相关的振荡，类似于体外整个脑干产生的振荡，并且在该区域鉴定出具有电压依赖性起搏器样特性的神经元。因此，哺乳动物新生儿神经系统的呼吸节律可能是由前波青格复合体中的条件性起搏器神经元群破裂引起的。
The location of neurons generating the rhythm of breathing in mammals is unknown. By microsection of the neonatal rat brainstem in vitro, a limited region of the ventral medulla (the pre-Botzinger Complex) that contains neurons essential for rhythmogenesis was identified. Rhythm generation was eliminated by removal of only this region. Medullary slices containing the pre-Botzinger Complex generated respiratory-related oscillations similar to those generated by the whole brainstem in vitro, and neurons with voltage-dependent pacemaker-like properties were identified in this region. Thus, the respiratory rhythm in the mammalian neonatal nervous system may result from a population of conditional bursting pacemaker neurons in the pre-Botzinger Complex.