Porphyrin localization: a new modality for detection and therapy of tumors.
Porphyrin localization: a new modality for detection and therapy of tumors.
复制标题
卟啉定位：肿瘤检测和治疗的新方式。
DOI：
10.1016/0006-2952(84)90403-9
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发表时间：
1984
影响因子：
5.8
通讯作者：
Kessel,D
中科院分区：
文献类型：
--
作者：
Kessel,D
这篇评论描述了使用卟啉进行肿瘤检测和治疗的最新进展。 1961年，Lipson等人[1]描述了注射一种名为“HPD”（血卟啉衍生物）的产品后卟啉在人类肿瘤中的定位，该产品是从血卟啉合成衍生的（图1）。尽管卟啉在肿瘤位点的积累已于 1924 年被描述[2]，但在 Lipson 的工作之前，对此现象的报道很少（总结于参考文献 3）。 HPD 被发现是一种优越的定位器，但最初只是实验室的好奇心。如下所述，仪器的发展使得 HPD 在临床上用于肿瘤定位和治疗变得可行。积累了卟啉的细胞具有光敏性，即随后暴露于光会产生细胞毒性后果。内源性卟啉的过量产生发生在称为卟啉症的病理状态下[4]，这与皮肤和其他组织的严重光催化损伤有关。如果卟啉的积累可以针对CH，
This commentary describes recent progress in the use of porphy~ ns for tumor detection and therapy. In 1961, Lipson et al.[l] described porphyrin localization in human tumors following injection of a product termed “HPD”(hematoporphyrin derivative), synthetically derived from hematoporphyrin (Fig. 1). Although accumulation of porphyrins at neoplastic loci had been described in 1924 [2], there were few reports (summa~ zed in Ref. 3) on the phenomenon prior to the work of Lipson. HPD was found to be a superior localizer but was, initially, something of a laboratory curiosity. Developments in instrumentation, described below, have now made feasible use of HPD in the clinic for both tumor localization and therapy. Cells that have accumulated porphyrins are photosensitized, ie subsequent exposure to light has cytotoxic consequences. An excess production of endogenous porphyrins occurs in a pathologic state called porphyria [4], which is associated with substantial light-catalyzed damage to skin and other tissues. If porphyrin a~ umulation could be targeted ti'CH,