Structural insight into the antibiotic action of telithromycin against resistant mutants
Structural insight into the antibiotic action of telithromycin against resistant mutants
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DOI：
10.1128/jb.185.14.4276-4279.2003
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发表时间：
2003-07-01
影响因子：
3.2
通讯作者：
Yonath, A
中科院分区：
文献类型：
--
作者：
Berisio, R;Harms, J;Yonath, A
与耐辐射球菌核糖体大亚基结合的酮内酯泰利霉素的晶体结构表明泰利霉素阻断核糖体出口通道并与23S RNA的结构域II和V相互作用。与其他临床相关的大环内酯类药物的比较提供了其对大环内酯类耐药菌株的增强活性的结构见解。
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.