Trends in hyperinsulinemia among nondiabetic adults in the US
Trends in hyperinsulinemia among nondiabetic adults in the US
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DOI：
10.2337/dc06-0289
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发表时间：
2006-11-01
期刊：
影响因子：
16.2
通讯作者：
Reaven, Gerald M.
中科院分区：
文献类型：
--
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
目的-胰岛素抵抗和代偿性高胰岛素血症被认为是多种异常和临床综合征的风险增加，包括2型糖尿病和心血管疾病。我们的目的是评估1988-1994年和1999-2002年期间美国非糖尿病成年人空腹血清胰岛素平均浓度和高胰岛素血症患病率的趋势。研究设计和方法-我们分析了第三次全国健康和营养检查调查中年龄为20岁的男性和非妊娠女性的数据。（NHANES III; 1988-1994; n = 7，926）和NHANES 1999 - 2002（n = 2，993）。这两项调查都是为了代表非制度化的美国平民人口。我们计算了年龄调整后的空腹胰岛素平均浓度以及使用非糖尿病个体空腹胰岛素第75百分位数作为临界值定义的高胰岛素血症患病率。结果-从1988-1994年到1999-2002年，空腹胰岛素的几何平均浓度增加了类似于5%在美国20岁的非糖尿病成年墨西哥裔美国男性中，年龄在20-39岁的男性和女性以及非西班牙裔白色女性的空腹胰岛素平均浓度的相对增加大于其对应者。高胰岛素血症的患病率总体增加了35.1%（男性为38.3%，女性为32.1%）。结论-与肥胖流行平行，非糖尿病美国成年人的空腹胰岛素浓度和高胰岛素血症的患病率显著增加。
OBJECTIVE - insulin resistance and compensatory hyperinsulinemia have been proposed as increasing risk for a variety of abnormalities and clinical syndromes, including type 2 diabetes and cardiovascular disease. Our aim was to assess the trends in the mean concentrations of fasting serum insulin and the prevalence of hyperinsulinemia among nondiabetic adults during the periods of 1988-1994 and 1999-2002 in the U.S.RESEARCH DESIGN AND METHODS - We conducted analyses of data among men and nonpregnant women without diabetes aged :20 years from the Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994; n = 7,926) and NHANES 19992002 (n = 2,993). Both surveys were designed to represent the noninstitutionalized civilian U.S. population. We calculated age-adjusted mean concentrations of fasting insulin and the prevalence of hyperinsulinemia defined using the 75th percentile of fasting insulin among nondiabetic individuals as the cutoff value.RESULTS - The geometric mean concentrations of fasting insulin increased by similar to 5% from 1988-1994 to 1999-2002 among nondiabetic adults aged 20 years in the U.S. Mexican-American men, men and women aged 20-39 years, and non-Hispanic white women had a greater relative increase in the mean concentrations of fasting insulin than their counterparts. The prevalence of hyperinsulinemia increased by 35.1% overall (38.3% among men and 32.1% among women).CONCLUSIONS - in parallel with the obesity epidemic, concentrations of fasting insulin and prevalence of hyperinsulinemia have increased remarkably among nondiabetic U.S. adults.