Skindex, a quality-of-life measure for patients with skin disease: Reliability, validity, and responsiveness
Skindex, a quality-of-life measure for patients with skin disease: Reliability, validity, and responsiveness
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DOI：
10.1111/1523-1747.ep12365600
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发表时间：
1996-11-01
影响因子：
6.5
通讯作者：
Zyzanski, SJ
中科院分区：
文献类型：
--
作者：
Chren, MM;Lasek, RJ;Zyzanski, SJ
为了衡量皮肤病对患者生活质量的影响，我们开发了一个61项自我管理的调查工具，称为Skindex，Skindex有8个量表，每个量表在一个全面的概念框架中解决一个结构或一个抽象组件：认知影响、社会影响、抑郁、恐惧、尴尬、愤怒、身体不适和身体限制，项目回答从0开始标准化（无影响）至100（最大效应）;量表得分是对涉及一个结构的项目的反应的平均值。在皮肤科医生看到的201名患者中，平均量表评分（+/- SD）范围为14（+/- 17）（身体限制）至31（+/- 22）（身体不适），72 h后量表评分可重现（r = 0.68 ~ 0.90），且内部一致（Cronbach’s alpha = 0.76 - 0.86），结构效度通过两种方式进行评估：（i）在患有炎性皮肤病的患者和患有孤立性病变的患者的比较中，患有炎性皮肤病的患者具有较高的量表评分，和（ii）在探索性因素分析中，78%的共同方差由与Skindex量表评分相关的7个因素解释，大多数先验量表评分在报告其皮肤状况在6个月后改善或恶化的患者中沿预期方向变化，最后，医生对疾病严重程度的判断与Skindex评分并不一致，这些初步数据表明，Skindex可靠且反应灵敏地测量了皮肤病对患者生活质量的影响，并可补充疾病严重程度的临床判断。
To measure the effects of skin disease on patients' quality of life, we developed a 61-item self-administered survey instrument called Skindex, Skindex has eight scales, each of which addresses a construct, or an abstract component, in a comprehensive conceptual framework: cognitive effects, social effects, depression, fear, embarrassment, anger, physical discomfort, and physical limitations, Item responses are standardized from 0 (no effect) to 100 (maximal effect); a scale score is the average of responses to items addressing a construct, In 201 patients seen by dermatologists, mean scale scores (+/- SD) ranged from 14 (+/- 17) for physical limitations to 31 (+/- 22) for physical discomfort, Scale scores were reproducible after 72 h (r = 0.68 - 0.90) and were internally consistent (Cronbach's alpha = 0.76 - 0.86), Construct validity was assessed in two ways: (i) in a comparison of patients with inflammatory dermatoses and patients with isolated lesions, patients with inflammatory dermatoses had higher scale scores, and (ii) in an exploratory factor analysis, 78% of the common variance was explained by seven factors that correlated with the scale scores of Skindex, Most of the a priori scale scores changed in the expected direction in patients who reported that their skin conditions had improved or worsened after 6 mo, Finally, physicians' judgments of disease severity did not consistently correlate with Skindex scores, These preliminary data suggest that Skindex reliably and responsively measures the effects of skin disease on patients' quality of life and may supplement clinical judgments of disease severity.