Mechanism and consequence of viral persistence in cells of the immune system and neurons.
Mechanism and consequence of viral persistence in cells of the immune system and neurons.
复制标题
病毒在免疫系统和神经元细胞中持续存在的机制和后果。
作者：
Oldstone,MB;Rall,GF
病毒持久性取决于病毒具有非裂解性复制策略和逃避免疫监视的能力。免疫系统的细胞（淋巴细胞/单核细胞/巨噬细胞）和中枢神经系统（神经元）最常被持续存在的DNA和RNA病毒感染。细胞毒性T淋巴细胞（CTL）是终止或防止病毒持续存在的主要宿主防御。本文探讨了病毒与这些特化细胞的相互作用以及这些感染细胞与CTL的相互作用。
Viral persistence depends on a virus having a non-lytic strategy of replication and the ability to escape immune surveillance. Cells of the immune system (lymphocytes/monocytes/macrophages) and central nervous system (neurons) are most often infected by DNA and RNA viruses that persist. Cytotoxic T lymphocytes (CTL) are the primary host defense that aborts or prevents viral persistence. Viral interaction with these specialized cells and of such infected cells with CTL is explored in this paper.