Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.
Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.
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DOI：
10.1016/j.ntt.2015.08.010
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发表时间：
2015-11
影响因子：
2.9
通讯作者：
Padilla S
中科院分区：
文献类型：
--
作者：
Jarema KA;Hunter DL;Shaffer RM;Behl M;Padilla S
随着多溴二苯醚的逐步淘汰，许多化合物正在作为潜在的替代阻燃剂出现，用于消费和电子产品。然而，人们对这些替代品的神经行为毒性知之甚少。本研究评估了急性或发育性暴露于磷酸叔丁基苯基二苯酯 (BPDP)、磷酸 2-乙基己基二苯酯 (EHDP)、磷酸异癸基二苯酯 (IDDP)、磷酸异丙基苯酯 (IPP)、磷酸三甲苯酯 (TMPP；也缩写为 TMPP) 的神经行为影响 TCP)、磷酸三苯酯(TPHP；也缩写为TPP)、四溴双酚A(TBBPA)、磷酸三(2-氯乙基)酯(TCEP)、磷酸三(1，3-二氯异丙基)酯(TDCIPP；也缩写为TDCPP)、磷酸三邻甲苯酯(TOCP)、 斑马鱼 (Danio rerio) 幼虫中的 2,2-,4,4'-四溴二苯醚 (BDE-47)。将幼虫（每剂量每种化合物 n ≈ 24 只）在发育或急性期暴露于亚致畸浓度的测试化合物（0.4–120 µM）中，并在受精后 6 天评估运动活性。在发育阶段给予时，除 BPDP、IDDP 和 TBBPA 之外的所有化学物质都会产生行为效应。当急性给药时，所有化学物质都会产生行为效应，其中 TPHP、TBBPA、EHDP、IPP 和 BPDP 在最高浓度下引起的效应最大。结果表明，这些替代阻燃剂可能对脊椎动物神经系统具有发育或药理作用。
As polybrominated diphenyl ethers are phased out, numerous compounds are emerging as potential replacement flame retardants for use in consumer and electronic products. Little is known, however, about the neurobehavioral toxicity of these replacements. This study evaluated the neurobehavioral effects of acute or developmental exposure to t-butylphenyl diphenyl phosphate (BPDP), 2-ethylhexyl diphenyl phosphate (EHDP), isodecyl diphenyl phosphate (IDDP), isopropylated phenyl phosphate (IPP), tricresyl phosphate (TMPP; also abbreviated TCP), triphenyl phosphate (TPHP; also abbreviated TPP), tetrabromobisphenol A (TBBPA), tris (2-chloroethyl) phosphate (TCEP), tris (1,3-dichloroisopropyl) phosphate (TDCIPP; also abbreviated TDCPP), tri-o-cresyl phosphate (TOCP), and 2,2-,4,4′-tetrabromodiphenyl ether (BDE-47) in zebrafish (Danio rerio) larvae. Larvae (n ≈ 24 per dose per compound) were exposed to test compounds (0.4–120 µM) at sub-teratogenic concentrations either developmentally or acutely, and locomotor activity was assessed at 6 days post fertilization. When given developmentally, all chemicals except BPDP, IDDP and TBBPA produced behavioral effects. When given acutely, all chemicals produced behavioral effects, with TPHP, TBBPA, EHDP, IPP, and BPDP eliciting the most effects at the most concentrations. The results indicate that these replacement flame retardants may have developmental or pharmacological effects on the vertebrate nervous system.