Profound Haemodynamic Response in the Prefrontal cortex Induced by Musical Stimuli
Profound Haemodynamic Response in the Prefrontal cortex Induced by Musical Stimuli
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发表时间：
2018
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通讯作者：
Y. Imamura;Yuki Murakami;K. Miura;Koji Miura;Takafumi Miyazaki;Keijiro Yamada;S. Mitani;Syohken Koh
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作者：
Y. Imamura;Yuki Murakami;K. Miura;Koji Miura;Takafumi Miyazaki;Keijiro Yamada;S. Mitani;Syohken Koh
前额叶皮质(PFC)活动的血氧动力学对感觉刺激(如音乐)的情绪反应是重要的。然而，参与PFC对音乐信息进行编码的局部神经元回路仍然未知。我们的目标是研究参与者在听不同属性的音乐作品时前额叶活动模式的变化。28名参与者(14名男性，14名女性)在听两首音乐(《Salut d‘Amour》和《盛况进行曲》)时，使用功能性近红外光谱(FNIRS)、心电图仪和脉搏血氧仪对他们的大脑功能进行了测试。在“隆重行军”期间，左侧前额前交叉韧带中的Δ氧合血红蛋白水平较“爱的礼炮”时显著降低。脑代谢的小波分析显示，“爱的祝福”在0.015-0.030赫兹之间改变了大脑的活动，而“盛况进行曲”在0.015赫兹稀疏地激活了大脑，在0.030赫兹激活了背外侧和眶前叶。这些发现表明，不同的音乐刺激对PFC中与神经活动相关的大脑代谢产生不同的影响。这些模式可能会揭示大脑处理音乐的潜在机制，以及音乐在促进心理健康和为人类生理状况创造更好环境方面的总体作用。
Blood-oxygen dynamics in response to prefrontal cortex (PFC) activity are important for emotional responses to sensory stimuli, such as music. However, the local neuronal circuits involved in the encoding of musical information by the PFC remain unknown. We aimed to examine alterations in prefrontal activity patterns while participants listened to musical pieces with different properties. Brain function was examined in 28 participants (14 men, 14 women) while they listened to two musical pieces (“Salut d’Amour” and “Pomp and Circumstance Marches”) using functional near-infrared spectroscopy (fNIRS), electrocardiography, and pulse oximetry. The delta oxyhemoglobin (ΔOxy-Hb) levels were significantly reduced in the left lateral PFC during “Pomp and Circumstance Marches”, relative to those observed during “Salut d’Amour”. Wavelet analyses of brain metabolism revealed that “Salut d’Amour” altered brain activity between 0.015-0.030 Hz, whereas “Pomp and Circumstance Marches” sparsely activated the brain at 0.015 Hz and activated the dorsolateral and orbitofrontal PFC at 0.030 Hz. These findings demonstrate that different musical stimuli exert differential effects on brain metabolism associated with neural activity in the PFC. These patterns may shed light on the mechanisms underlying music processing in the brain, and the overall role of music in promoting mental health and creation of better circumstances for physiological conditions in human.