Lower plasma vitamin e levels are associated with the frailty syndrome: The InCHIANTI study
Lower plasma vitamin e levels are associated with the frailty syndrome: The InCHIANTI study
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DOI：
10.1093/gerona/61.3.278
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发表时间：
2006-03-01
影响因子：
5.1
通讯作者：
Ferrucci, L
中科院分区：
文献类型：
--
作者：
Ble, A;Cherubini, A;Ferrucci, L
背景导致老年人虚弱的主要生物机制从未得到充分解释。根据最近的观点，氧化应激可能是这种情况的驱动力。我们检验了这一假设，即独立于混杂因素，低血浆水平的维生素E（α-locopherol），主要的脂溶性人类抗氧化剂，与老年人的脆弱综合征无痴呆和残疾。研究样本包括827名老年人（>= 65岁）（女性，54%），他们参加了一项基于人群的流行病学研究。虚弱的参与者是根据以下特征中至少三个的存在来确定的：自我报告的体重减轻、低能量、缓慢的步态速度、低握力和低体力活动。没有这些特征的参与者被认为是非虚弱的，而有一个或两个特征的参与者被认为是中度虚弱的。采用反相高效液相色谱法测定血浆维生素E水平。测量的混杂因素包括下肢肌力、认知功能、疾病和与维生素E代谢相关的因素。年龄和性别调整后的维生素E水平从非虚弱组到虚弱组逐渐下降（趋势p = 0.015）。在调整多个潜在混杂因素的logistic模型中，维生素E水平最高的三分位数的参与者比维生素E水平最低的三分位数的参与者更不容易虚弱（比值比，0.30; 95%置信区间，0.10-0.91）。我们的研究结果表明，人体抗氧化系统中最重要的成分之一的低循环水平与虚弱之间存在关联。
Background. The primary biologic mechanism that causes frailty in older persons has never been adequately explained. According to recent views, oxidative stress may be the driving force of this condition. We tested the hypothesis that, independent of confounders, low plasma levels of vitamin E (alpha-locopherol), the main fat-soluble human antioxidant, are associated with the frailty syndrome in older persons free from dementia and disability.Methods. The study sample included 827 older (>= 65 years) persons (women, 54%) who participated in a population based epidemiological study. Frail participants were identified based on the presence of at least three of live of the following features: self-reported weight loss, low energy, slow gait speed, low grip strength, and low physical activity. Participants with none of these features were considered nonfrail, while participants with one or two were considered intermediate frail. Plasma vitamin E levels were determined using reverse-phase high-performance liquid chromatography. Measured confounders included lower extremity muscle strength, cognitive function, diseases, and factors related to vitamin E metabolism.Results. Age- and gender-adjusted levels of vitamin E decreased gradually from the nonfrail to the frail group (p for trend=.015). In the logistic model adjusted for multiple potential confounders, participants in the highest vitamin E tertile were less likely to be frail than were participants in the lowest vitamin E tertile (odds ratio, 0.30; 95% confidence interval, 0.10-0.91).Conclusions. Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty.