Mechanisms of mammalian otoacoustic emission and their implications for the clinical utility of otoacoustic emissions
Mechanisms of mammalian otoacoustic emission and their implications for the clinical utility of otoacoustic emissions
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DOI：
10.1097/01.aud.0000121200.90211.83
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发表时间：
2004-04-01
期刊：
影响因子：
3.7
通讯作者：
Shera, CA
中科院分区：
文献类型：
--
作者：
Shera, CA
我们回顾了在理解产生耳声发射（OAE）的物理和生理机制方面的最新进展。直到最近，解释 OAE 的概念模型一直是一种综合观点，将所有 OAE 视为耳蜗非线性的表现。然而，OAE 似乎是由耳蜗内至少两种根本不同的机制引起的：非线性失真和线性反射。这些机制上的差异已被用来构建 OAE 的新分类法，该分类法根据 OAE 的生成机制而不是测量细节来识别 OAE。基于机制的分类法为理解和解释耳声反应提供了有用的概念框架。正如临床上通常测量的那样，畸变产物和其他诱发的 OAE 包含两种机制产生的排放混合物。这种混合排除了与传统的、基于测量的命名法的任何固定对应关系。我们讨论分类法对 OAE 临床测量和解释的影响。
We review recent progress in understanding the physical and physiological mechanisms that generate otoacoustic emissions (OAEs). Until recently, the conceptual model underlying the interpretation of OAEs has been an integrated view that regards all OAEs as manifestations of cochlear nonlinearity. However, OAEs appear to arise by at least two fundamentally different mechanisms within the cochlea: nonlinear distortion and linear reflection. These differences in mechanism have be used to construct a new taxonomy for OAEs that identifies OAEs based on their mechanisms of generation rather than the details of their measurement. The mechanism-based taxonomy provides a useful conceptual framework for understanding and interpreting otoacoustic responses. As commonly measured in the clinic, distortion-product and other evoked OAEs comprise a mixtures of emissions produced by both mechanisms. This mixing precludes any fixed correspondence with the conventional, measurement-based nomenclature. We discuss consequences of the taxonomy for the clinical measurement and interpretation of OAEs.