Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder
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DOI：
10.1093/ajcn/71.1.327s
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发表时间：
2000-01-01
影响因子：
7.1
通讯作者：
Peck, L
中科院分区：
文献类型：
--
作者：
Burgess, JR;Stevens, L;Peck, L
注意力缺陷多动障碍（ADHD）是用于描述注意力不集中，冲动和多动的儿童的诊断。ADHD是一种普遍存在的疾病，是公共卫生问题。在大多数儿童多动症的原因是未知的，但被认为是生物和多因素。先前的几项研究表明，ADHD中报告的一些身体症状与在缺乏必需脂肪酸（EFA）的动物和人类中观察到的症状相似。我们以前曾报道过，一个亚组的ADHD受试者报告了许多EFA缺乏症（L-ADHD）的症状，血浆花生四烯酸和二十二碳六烯酸的比例显着低于ADHD受试者很少这样的症状或对照组。在另一项使用血浆极性脂质数据对比分析的研究中，总n-3脂肪酸组成较低的受试者比n-3脂肪酸比例高的受试者有更多的行为问题，脾气暴躁，学习，健康和睡眠问题。这些儿童中长链多不饱和脂肪酸（LCPUFA）比例较低的原因尚不清楚;然而，涉及脂肪酸摄入，EFA转化为LCPUFA产品和代谢增强的因素进行了讨论。LCPUFA状态与儿童表现出的行为问题之间的关系也不清楚。目前，我们正在对临床诊断为ADHD并表现出EFA缺乏症状的儿童进行双盲、安慰剂对照干预，以测试这种关系。
Attention-deficit hyperactivity disorder (ADHD) is the diagnosis used to describe children who are inattentive, impulsive, and hyperactive. ADHD is a widespread condition that is of public health concern. In most children with ADHD the cause is unknown, but is thought to be biological and multifactorial. Several previous studies indicated that some physical symptoms reported in ADHD are similar to symptoms observed in essential fatty acid (EFA) deficiency in animals and humans deprived of EFAs. We reported previously that a subgroup of ADHD subjects reporting many symptoms indicative of EFA deficiency (L-ADHD) had significantly lower proportions of plasma arachidonic acid and docosahexaenoic acid than did ADHD subjects with few such symptoms or control subjects. In another study using contrast analysis of the plasma polar lipid data, subjects with lower compositions of total n-3 fatty acids had significantly more behavioral problems, temper tantrums, and learning, health, and sleep problems than did those with high proportions of n-3 fatty acids. The reasons for the lower proportions of long-chain polyunsaturated fatty acids (LCPUFAs) in these children are not clear; however, factors involving fatty acid intake, conversion of EFAs to LCPUFA products, and enhanced metabolism are discussed. The relation between LCPUFA status and the behavior problems that the children exhibited is also unclear. We are currently testing this relation in a double-blind, placebo-controlled intervention in a population of children with clinically diagnosed ADHD who exhibit symptoms of EFA deficiency.