Individual comparisons of the levels of (E)-3-methyl-2-hexenoic acid, an axillary odor-related compound, in Japanese
Individual comparisons of the levels of (E)-3-methyl-2-hexenoic acid, an axillary odor-related compound, in Japanese
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DOI：
10.1093/chemse/bjj060
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发表时间：
2006-07-01
期刊：
影响因子：
3.5
通讯作者：
Sakurada, Koichi
中科院分区：
文献类型：
--
作者：
Akutsu, Tomoko;Sekiguchi, Kazurnasa;Sakurada, Koichi
(E)-3-甲基-2-己烯酸 (E3M2H) 是一种与腋臭相关的化合物，已知存在于白种人中。本研究的目的是阐明 E3M2H 是否会导致亚洲人腋臭，并量化和比较 E3M2H 的个体水平。 E3M2H 的定量测定是通过气相色谱-质谱法对日本受试者穿着 24 小时 T 恤腋下区域提取的汗液进行的。 30 名受试者中有 6 名的 E3M2H 量为 15.9-34.6 nmol/ml。我们的方法成功地对单独采集的腋汗中的 E3M2H 进行了定量分析；我们还表明，E3M2H 可以在亚洲人中检测到。这是第一份对个体腋窝汗液中 E3M2H 量进行量化并进行比较以揭示个体差异的报告。这项研究的结果表明，E3M2H 可能会导致亚洲人和白种人的腋臭。
The (E)-3-methyl-2-hexenoic acid (E3M2H), an axillary odor-related compound, is known to occur in Caucasians. The aims of this study were to clarify whether E3M2H contributes to axillary odor in Asians and to quantify and compare individual levels of E3M2H. Quantitative determination of E3M2H was performed by means of gas chromatography-mass spectrometry of sweat extracted from the axillary areas of T-shirts worn for 24 h by Japanese subjects. The amount of E3M2H was 15.9-34.6 nmol/ml in six of 30 subjects. Our method succeeded in quantitative analysis of E3M2H from axillary sweat collected individually; we also showed that E3M2H could be detected in Asians. This is the first report in which the amount of E3M2H in axillary sweat was quantified on an individual basis and compared to reveal individual differences. The results of this study indicate that E3M2H might contribute to axillary malodor in Asians as well as Caucasians.