The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer.
The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer.
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DOI：
10.7150/jca.62352
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发表时间：
2021
影响因子：
3.9
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Zhang Y;Huang S;Yang G;Zou L;Huang X;Liu S
消化道癌症是世界上癌症死亡率的主要原因之一。尽管进行了一些研究，但治疗消化道癌症的确切机制尚未完全了解。为了生存，消化道癌细胞受到各种内部和外部不利因素的影响，如缺氧、营养缺乏或药物毒性，导致错误折叠和未折叠蛋白在内质网（ER）腔内积聚，进一步导致ER应激和未折叠蛋白反应（UPR）。近年来，关于内质网应激与microRNAs（miRNAs）关系的研究不断涌现。miRNA是一种长度为21~22个核苷酸的非编码RNA，参与基因表达的转录后调节，可以被视为肿瘤诱导因子（oncomiRs）和肿瘤抑制因子，通过不同地影响癌细胞信号相关基因的表达来调节癌细胞的增殖、侵袭和凋亡。因此，研究ER应激和miRNA之间的相互作用对于开发有效的癌症治疗和预防策略至关重要。本文就miRNAs在消化道肿瘤细胞内质网应激诱导细胞凋亡中的调控作用进行综述，阐述其作用机制，为寻找消化道肿瘤新的治疗靶点提供理论基础。
Digestive cancer is one of the leading causes of cancer mortality in the world. Despite a number of studies being conducted, the exact mechanism for treating digestive cancer has not yet been fully understood. To survive, digestive cancer cells are subjected to various internal and external adverse factors, such as hypoxia, nutritional deficiencies or drug toxicity, resulting in accumulation of misfolded and unfolded protein in endoplasmic reticulum (ER) lumen further leading to ER stress and the unfolded protein response (UPR). During the last years, studies on the relationship between ER stress and microRNAs (miRNAs) has burst on the scene. miRNAs are non-coding RNAs with a length of 21~22nucleotides involved in post-transcriptional regulation of gene expression, which could be regarded as oncomiRs (tumor inducers) and tumor suppressors regulating cancer cell proliferation, invasion, and apoptosis by differently affecting the expression of genes related to cancer cell signaling. Therefore, investigating the interaction between ER stress and miRNAs is crucial for developing effective cancer treatment and prevention strategies. In this review, we mainly discuss miRNAs focusing on its regulation, role in ER stress induced apoptosis in Digestive cancer, expound the underlying mechanism, thus provides a theoretical foundation for finding new therapeutic targets of digestive cancer.
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影响因子：
14.8
作者：
Grandjean JMD;Madhavan A;Cech L;Seguinot BO;Paxman RJ;Smith E;Scampavia L;Powers ET;Cooley CB;Plate L;Spicer TP;Kelly JW;Wiseman RL
通讯作者：
Wiseman RL
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影响因子：
8.8
作者：
He, G. Y.;Hu, J. L.;Zhou, L.;Zhu, X. H.;Xin, S. N.;Zhang, D.;Lu, G. F.;Liao, W. T.;Ding, Y. Q.;Liang, L.
通讯作者：
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影响因子：
4
作者：
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通讯作者：
Sun G
影响因子：
6.1
作者：
Hu, Zhi-Hao;Wang, Guo-Jun;Hu, Xiu-Mei
通讯作者：
Hu, Xiu-Mei
影响因子：
4.2
作者：
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Zhao, Zengren