Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents.
Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents.
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III 组和 IV 组肌肉传入对葡萄糖调节运动反应的反射控制。
DOI：
10.1152/ajpregu.1994.266.3.r824
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Mitchell,JH
中科院分区：
文献类型：
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作者：
Vissing,J;Iwamoto,GA;Fuchs,IE;Galbo,H;Mitchell,JH
第三类和第四类肌肉传入在运动过程中是活跃的，传递来自肌肉中机械和代谢物受体的信息。我们假设这些传入神经参与了运动的内分泌和代谢调节。10只麻醉瘫痪猫分别以3、20、140倍运动阈值电刺激股神经肌支，每种强度电刺激10min，以20倍运动阈值电刺激III组，140倍运动阈值电刺激III、IV组。六只猫没有受到刺激，但被视为受刺激的猫。静脉输注葡萄糖，并采集动脉血进行底物和激素分析。三次运动阈值刺激对测量的代谢参数无影响。20倍运动阈值刺激可使大鼠血糖(8.2±1.8mmol.min-1·kg-1)、血糖(0.29±0.07 mmol.min-1)和促肾上腺皮质激素(ACTH35+/-12pg/ml)升高(P<；0.05)。140倍运动阈值刺激可使血糖(10.2+/-5.4mmol.min-1·kg-1)、血糖(0.53+/-0.10 mmol/L)、促肾上腺皮质激素(94+/-28pg/ml)、β-内啡肽(17+/-6pg/ml)和甲硫氨酸脑啡肽(15+/-2pg/ml)升高(P<；0.05与对照组相比)，胰岛素(0.65+/-0.14微U/ml)降低(P<；0.05与对照组相比)。甘油和胰升糖素不随刺激而变化。这一发现为运动过程中肌肉对激素分泌和葡萄糖动员的反射控制提供了证据。
Group III and IV muscle afferents are active during exercise and relay information from mechano- and metaboreceptors in muscle. We hypothesized that these afferents participate in the regulation of endocrine and metabolic adjustments to exercise. Muscle branches of the femoral nerves were electrically stimulated in 10 anesthetized and paralyzed cats at 3, 20, and 140 times motor threshold, for 10 min at each intensity, recruiting group III afferents at 20 times motor threshold and group III and IV afferents at 140 times motor threshold. Six cats were not stimulated but were otherwise treated as stimulated cats. [3-3H]glucose was infused intravenously, and arterial blood was sampled for analysis of substrates and hormones. Three times motor threshold stimulation induced no changes in measured metabolic parameters. Twenty times motor threshold stimulation elicited increases (P < 0.05 vs. control) in glucose production (8.2 +/- 1.8 mumol.min-1.kg-1) and plasma glucose (0.29 +/- 0.07 mmol/l) and adrenocorticotropic hormone (ACTH; 35 +/- 12 pg/ml). Stimulation at 140 times motor threshold elicited increases (P < 0.05 vs. control) in glucose production (10.2 +/- 5.4 mumol.min-1.kg-1), plasma glucose (0.53 +/- 0.10 mmol/l), ACTH (94 +/- 28 pg/ml), beta-endorphin (17 +/- 6 pg/ml), and Met-enkephalin (15 +/- 2 pg/ml) and decreases (P < 0.05 vs. control) in insulin (0.65 +/- 0.14 microU/ml). Glycerol and glucagon did not change with stimulations. The findings provide evidence for a reflex control from muscle of hormone secretion and mobilization of glucose during exercise.