Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes.
Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes.
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DOI：
10.18632/oncotarget.26178
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发表时间：
2018-10-09
期刊：
影响因子：
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通讯作者：
Baroni, Marco Giorgio
中科院分区：
文献类型：
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作者：
Bertoccini, Laura;Bailetti, Diego;Baroni, Marco Giorgio
2型糖尿病（T2 D）的死亡率增加。低维生素D水平与T2 D死亡风险增加相关。在一般人群中，影响维生素D代谢的遗传变异（DHCR 7 rs 12785878、CYP 2 R1 rs 10741657、GC rs 4588）与血清维生素D相关。我们研究了来自“Sapienza大学糖尿病死亡率和死亡事件率（SUMMER）研究”的2163例T2 D患者中这些变异与血清维生素D的相关性。血清维生素D的测量是集中的。通过Eco Real-Time PCR获得基因型。根据性别、年龄、BMI、HbA 1c、T2 D治疗和采样季节调整数据。DHCR 7 rs 12785878（p = 1 x 10-4）和GC rs 4588（p = 1 x 10-6）与维生素D水平显著相关，但CYP 2 R1 rs 10741657（p = 0.31）与维生素D水平无关。一个单位的加权基因型风险评分（GRS）与维生素D水平（p = 1.1 x 10-11）和维生素D不足（
Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes". Measurements of serum vitamin D were centralised. Genotypes were obtained by Eco Real-Time PCR. Data were adjusted for gender, age, BMI, HbA1c, T2D therapy and sampling season. DHCR7 rs12785878 (p = 1 x 10-4) and GC rs4588 (p = 1 x 10-6) but not CYP2R1 rs10741657 (p = 0.31) were significantly associated with vitamin D levels. One unit of a weighted genotype risk score (GRS) was strongly associated with vitamin D levels (p = 1.1 x 10-11) and insufficiency (