Spatiotemporal signatures of an abnormal auditory system in stuttering
Spatiotemporal signatures of an abnormal auditory system in stuttering
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DOI：
10.1016/j.neuroimage.2010.12.083
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发表时间：
2011-04-01
期刊：
影响因子：
5.7
通讯作者：
Tobimatsu, Shozo
中科院分区：
文献类型：
--
作者：
Kikuchi, Yoshikazu;Ogata, Katsuya;Tobimatsu, Shozo
口吃者（PWS）在掩蔽噪声和改变的听觉反馈下可以降低口吃率：这种反应可以归因于改变的听觉输入，这表明PWS中的异常言语加工是由听觉输入的异常加工引起的。然而，这种基本听觉信息异常处理的细节仍然不清楚。为了表征这种异常，我们研究了PWS听觉皮层的功能和结构变化，使用306通道脑磁图系统，以评估听觉感觉门控（P50 m抑制）和tonotopic组织。此外，我们采用基于体素的形态学比较皮质灰质（GM）的结构MR图像的体积。PWS表现为左侧听觉感觉门控受损。与对照组相比，PWS组右半球的音调分布结构扩大。此外，PWS显示右侧上级颞回的GM体积显著增加，与右侧色调扩张一致。因此，我们认为PWS在基本的听觉输入过程中损害了左侧听觉感觉门控，并且听觉皮层中的某些错误信号可能导致异常的语音处理。右侧听觉皮层的功能和结构重组似乎是PWS中左侧听觉皮层功能受损的补偿机制。(C)2011 Elsevier Inc. All rights reserved.
People who stutter (PWS) can reduce their stuttering rates under masking noise and altered auditory feedback: such a response can be attributed to altered auditory input, which suggests that abnormal speech processing in PWS results from abnormal processing of auditory input. However, the details of this abnormal processing of basic auditory information remain unclear. In order to characterize such abnormalities, we examined the functional and structural changes in the auditory cortices of PWS by using a 306-channel magnetoencephalography system to assess auditory sensory gating (P50m suppression) and tonotopic organization. Additionally, we employed voxel-based morphometry to compare cortical gray matter (GM) volumes on structural MR images. PWS exhibited impaired left auditory sensory gating. The tonotopic organization in the right hemisphere of PWS is expanded compared with that of the controls. Furthermore, PWS showed a significant increase in the GM volume of the right superior temporal gyrus, consistent with the right tonotopic expansion. Accordingly, we suggest that PWS have impaired left auditory sensory gating during basic auditory input processing and that some error signals in the auditory cortex could result in abnormal speech processing. Functional and structural reorganization of the right auditory cortex appears to be a compensatory mechanism for impaired left auditory cortex function in PWS. (C) 2011 Elsevier Inc. All rights reserved.