Solid-state Silver-catalyzed Ring-opening Fluorination of Cyclobutanols Using Mechanochemistry
Solid-state Silver-catalyzed Ring-opening Fluorination of Cyclobutanols Using Mechanochemistry
复制标题
利用机械化学进行固态银催化环丁醇开环氟化
作者：
Isshiki Ryota;Kubota Koji;Ito Hajime
在本报告中，我们证明了球磨技术促进了环丁醇的快速和有效的银催化开环氟化。这是固体机械化学条件下催化C-C键裂解/功能化反应的首次报道。开发的方案在更短的反应时间内提供了γ-氟化酮的高收率，并且与以前的基于溶液的条件相比，需要更少的银催化剂和selectflur。值得注意的是，该过程可以在空气中进行。由于减少了化学品的使用和简单的节省时间的实验程序，该技术是一种高效和环保的方式来获取γ-氟化酮。
In this report, we demonstrate that a ball-milling technique facilitates fast and efficient silver-catalyzed ring-opening fluorination of cyclobutanols. This is the first report of a catalytic C–C bond-cleavage/functionalization reaction under solid-state mechanochemical conditions. The developed protocol affords a high yield of γ-fluorinated ketones within much shorter reaction times, and requires less silver catalyst and Selectfluor compared with the previous solution-based conditions. Notably, the process can be carried out in air. Because of the reduced use of chemicals and the simple time-saving experimental procedures, this technique is an efficient and environmentally friendly way to access γ-fluorinated ketones.