Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients
Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients
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血液透析患者血清鸢尾素水平降低与血管钙化增加相关
DOI：
10.1159/000487689
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Zhang, Ai-Hua
中科院分区：
文献类型：
--
作者：
He, Lian;He, Wan-Yu;Zhang, Ai-Hua
背景/目的：血管钙化在透析患者中很普遍，它涉及血管平滑肌细胞向骨形成细胞的活跃转化，并预测其死亡率。它的机制很复杂，也不清楚。我们推测，虹膜蛋白，一种新发现的肌细胞因子，也可能在血液透析患者的血管钙化中发挥作用。本研究旨在评估血液透析患者的血清虹膜蛋白水平，并建立其与血管钙化及其他参数的关系。方法：150名维持性血液透析患者和38名年龄和性别匹配的健康对照参加这项横断面研究。采用双抗体夹心酶联免疫吸附试验测定血清淫羊藿素浓度。通过腹主动脉钙化评分评价血管钙化程度。结果：血液透析患者血清淫羊藿素浓度显著低于对照组[52.8(2 2.0,100.0)ng/ml比460.8(434.8,483.4)ng/ml，P
Background/Aims: Vascular calcification, which involves an active cellular transformation of vascular smooth muscle cells into bone forming cells, is prevalent and predicts mortality in dialysis patients. Its mechanisms are complex and unclear. We presume that irisin, a newly identified myokine also may play roles in vascular calcification in hemodialysis patients. This study aims to evaluate serum irisin levels and establish their relation to vascular calcification and other parameters in hemodialysis patients. Methods: A total of 150 patients on maintenance hemodialysis treatment and 38 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentrations were measured by ELISA. Vascular calcification was evaluated by abdominal aortic calcification scores. Results: Serum irisin concentrations were significantly lower in hemodialysis patients than in controls [52.8 (22.0, 100.0) vs. 460.8 (434.8, 483.4) ng/ml, P