The insulin-like growth factor system.
The insulin-like growth factor system.
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DOI：
10.1155/edr.2003.205
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发表时间：
2003-10
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影响因子：
--
通讯作者：
Le Roith D
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文献类型：
--
作者：
Le Roith D
胰岛素样生长因子（IGF）系统无处不在，在身体的每个组织中发挥着作用。它由配体、受体和结合蛋白组成，每种都具有特定的功能。虽然 IGF 系统在胚胎和产后发育中发挥着重要作用，但它在正常成人生理学中也很重要。现在有许多疾病的例子，例如糖尿病、癌症和营养不良，IGF系统在这些疾病中起着主要作用，毫不奇怪，人们试图通过操纵该系统来影响这些疾病。
The insulin-like growth factor (IGF) system in ubiquitous and plays a role in every tissue of the body. It is comprised of ligands, receptors and binding proteins, each with specific functions. While it plays an essential role in embryonic and post-natal development, the IGF system is also important in normal adult physiology. There are now numerous examples of diseases such as diabetes, cancer, and malnutrition in which the IGF system is a major player and, not surprisingly, there are attempts to affect these disorders by manipulating the system.