Steroidogenic cytochromes P450: do the properties of the homogeneous enzymes reveal important aspects of the regulation of steroid synthesis in vivo?
Steroidogenic cytochromes P450: do the properties of the homogeneous enzymes reveal important aspects of the regulation of steroid synthesis in vivo?
复制标题
类固醇生成细胞色素 P450：均质酶的特性是否揭示了体内类固醇合成调节的重要方面？
DOI：
10.1080/07435808409036503
复制
发表时间：
1984
影响因子：
2.1
通讯作者：
Hall,PF
中科院分区：
文献类型：
--
作者：
Hall,PF
Since each of the cytochromes P450 that catalyze reactions responsible for drug metabolism is capable of catalyzing numerous reactions with a bewildering array of substrates, we may consider whether the properties of each of the pure xenobiotic enzymes will really tell us much about the regulation of drug metabolism. Apart from possible changes that may occur in a protein during purification, it would seem that this family of enzymes has low specificity, overlapping activity between different enzymes and the ability to catalyze different types of reactions with different substrates% e following discussion presents a survey of recent information regarding the steroidogenic cytochromes P450 and whether such constraints apply to these enzymes. a= SysLem. In addition to the C27-or cholesterol side-chain cleavage system in the inner mitochondria1 membrane discussed by Dr. Lambeth, the microsomal compartment of the Leydiq cell contains a C21-steroid side-chain cleavage system (1) that was formerly believed to be catalyzed by two separate
