Practice effects distort translational validity estimates for a Neurocognitive Battery
Practice effects distort translational validity estimates for a Neurocognitive Battery
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DOI：
10.1080/13803395.2015.1037253
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发表时间：
2015-05-28
影响因子：
2.2
通讯作者：
Nimgaonkar, Vishwajit
中科院分区：
文献类型：
--
作者：
Ibrahim, Ibtihal;Tobar, Salwa;Nimgaonkar, Vishwajit
导言：随着生物医学研究的全球化和“精确医学”的出现，对神经心理测试的翻译需求增加，例如可以结合到大规模基因组研究中的计算机化电池。翻译效度的评估是通过对双语个体进行原文和译文中的测试来获得的。我们调查了一组神经心理学资料从英语到阿拉伯语的翻译，以及练习效果如何影响翻译效度估计。方法：宾夕法尼亚州立大学计算机化神经认知成套测验(Penn CNB)包括经功能神经成像验证的测试，并提供几个认知领域操作的准确性和速度的测量。为了开发阿拉伯版本的《国家预算草案》，英文版被翻译成阿拉伯文，然后再翻译回来并加以修订。本研究采用随机交叉设计，对22名双语受试者进行了阿拉伯语和英文原文版本的测试。结果：表现因认知领域不同而不同，但在第二次测试中，无论最初测试的语言是什么，总体上都有所改善。当比较英语版和阿拉伯语版的成绩时，在8/13认知领域的准确性和4/13领域的速度之间存在显著的正相关(r=0.02到0.97)。当使用线性模型的实践估计被纳入时，翻译有效性估计显著提高(准确度，r=.50-.96，速度，r=.63-.92，所有相关性，p=0.05或更好)。结论：虽然交叉设计了顺序效应对平均成绩的控制，但仍然需要去除练习效应，无论语言如何，以获得翻译效度的估计。在控制练习效果的情况下，Penn-CNB的阿拉伯语和英语版本有较好的相关性，阿拉伯语版本适合用于研究。
Introduction: With the globalization of biomedical research and the advent of "precision medicine," there is increased need for translation of neuropsychological tests, such as computerized batteries that can be incorporated in large-scale genomic studies. Estimates of translational validity are obtained by administering the test in the original and the translated versions to bilingual individuals. We investigated the translation of a neuropsychological battery from English to Arabic and how practice effects influence translational validity estimates. Methods: The Penn computerized neurocognitive battery (Penn CNB) includes tests that were validated with functional neuroimaging and provides measures of accuracy and speed of performance in several cognitive domains. To develop an Arabic version of the CNB, the English version was translated into Arabic, then back translated and revised. The Arabic and the original English versions were administered in a randomized crossover design to bilingual participants (N = 22). Results: Performance varied by cognitive domain, but generally improved at the second session regardless of the language of the initial test. When performance on the English and Arabic version was compared, significant positive correlations were detected for accuracy in 8/13 cognitive domains and for speed in 4/13 domains (r = .02 to .97). When the practice estimates using linear models were incorporated, the translational validity estimates improved substantially (accuracy, r = .50-.96, speed, r = .63-.92, all correlations, p = .05 or better). Conclusion: While crossover designs control for order effects on average performance, practice effects, regardless of language, still need to be removed to obtain estimates of translational validity. When practice effect is controlled for, the Arabic and English versions of the Penn-CNB are well correlated, and the Arabic version is suitable for use in research.