Change in diffusion weighted MRI during liver cancer radiotherapy: Preliminary observations
Change in diffusion weighted MRI during liver cancer radiotherapy: Preliminary observations
复制标题
DOI：
10.1080/02841860903099972
复制
发表时间：
2009-01-01
期刊：
影响因子：
3.1
通讯作者：
Dawson, Laura A.
中科院分区：
文献类型：
--
作者：
Eccles, Cynthia L.;Haider, Ehsan A.;Dawson, Laura A.
目的.探讨弥散加权磁共振成像（DWI）在肝脏和肝癌适形放疗（RT）中的应用价值。确定使用表观扩散系数（ADC）变化作为肿瘤控制或正常组织损伤的潜在替代物的可行性。材料和方法。六部分适形肝脏RT协议的患者进行DW-MRI在治疗计划的时间，在RT（第一周和第二周）和RT后一个月。扩散加权MR图像采集在呼气屏气，使用0和600的b值。在ADC图上分析对应于最大肿瘤剂量、高剂量肿瘤周围肝脏、辐照的正常肝脏、未辐照的肝脏和脾脏的感兴趣区域（ROI）。结果对11例患者（4例肝细胞癌，5例肝转移，2例胆管癌）进行了评价。基线时肿瘤ADC中位数为1.56 × 10 - 3 mm 2/sec，RT第1周时增至1.89 × 10 - 3 mm 2/sec，第2周增至1.91 × 10 - 3 mm 2/sec，治疗后1个月增至2.01 × 10 - 3 mm 2/sec（p
Purpose. To evaluate diffusion weighted magnetic resonance imaging (DWI) in liver and liver cancers during and following conformal radiotherapy (RT). To determine the feasibility of using changes in apparent diffusion coefficients (ADC) as a potential surrogate for tumour control or normal tissue injury. Materials and methods. Patients on a six-fraction conformal liver RT protocol underwent DW-MRI at the time of treatment planning, during RT (week one and two) and one month following RT. Diffusion weighted MR images were acquired in exhale breath hold, using b-values of 0 and 600. Regions of interest (ROIs) corresponding to maximal tumour dose, high-dose peri-tumour liver, irradiated normal liver, non-irradiated liver, and spleen were analyzed on ADC maps. Results. Eleven patients (four hepatocellular carcinoma, five liver metastases, two cholangiocarcinoma) were evaluated. The baseline median tumour ADC of 1.56 x 10(-3) mm(2)/sec increased to 1.89 x 10(-3) mm(2)/sec at RT week one, to 1.91 x 10(-3) mm(2)/sec during week two and to 2.01 x 10(-3) mm(2)/sec at one month following treatment (p