Synthesis of tertiary propargylamines by sequential reactions of in situ generated thioiminium salts with organolithium and -magnesium reagents
Synthesis of tertiary propargylamines by sequential reactions of in situ generated thioiminium salts with organolithium and -magnesium reagents
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DOI：
10.1021/ja048627v
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发表时间：
2004-05-19
影响因子：
15
通讯作者：
Murakami, M
中科院分区：
文献类型：
--
作者：
Murai, T;Mutoh, Y;Murakami, M
由硫酰胺和三氟酸甲酯生成的硫胺盐与有机锂和镁试剂的顺序反应顺利进行，得到中高收率的叔丙胺。在所有情况下，两种不同的有机金属试剂被纳入起始硫胺。
Sequential reactions of thioiminium salts generated from thioamides and methyl triflate with organolithium and -magnesium reagents proceed smoothly to give tertiary propargylamines in moderate to high yields. In all cases, two different organometallic reagents are incorporated into the starting thioamides.