DEFICIENT EXPRESSION OF COSTIMULATORY MOLECULES ON LEISHMANIA-INFECTED MACROPHAGES
DEFICIENT EXPRESSION OF COSTIMULATORY MOLECULES ON LEISHMANIA-INFECTED MACROPHAGES
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DOI：
10.1002/eji.1830241140
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发表时间：
1994-11-01
影响因子：
5.4
通讯作者：
SCOTT, JC
中科院分区：
文献类型：
--
作者：
KAYE, PM;ROGERS, NJ;SCOTT, JC
Co-stimulatory signals are necessary for the full activation of T cells for growth and effector function. As co-stimulatory molecules are normally regulated in their expression, it has been suggested that microorganisms enhance their expression on host antigen-presenting cells (APC), thus allowing efficient generation of anti-microbial immunity. We here describe experiments which demonstrate that infection of macrophages, both in vitro and in vivo, by the protozoan parasite Leishmania donovani fails to trigger expression of costimulatory molecules B7-1 and heat-stable antigen on these APC. Furthermore, infection with this parasite inhibits the macrophage response to normal regulatory signals, such as bacterial lipopolysaccharide. These changes in the cell surface are mirrored in functional studies of co-stimulation in vitro. Together, these data suggest a further facet of parasite interference in host immunity, but also indicate a potential new target for immunotherapy.
